Albuminuria and reduced glomerular filtration rate for predicting the renal outcomes in type 2 diabetic patients

Nephrology
Nobue TanakaYasuko Uchigata

Abstract

The first clinical manifestation of diabetic kidney disease is usually the development of microalbuminuria. However, recent studies have focused on diabetic patients with reduced glomerular filtration rate (GFR) without albuminuria. To evaluate the association of albuminuria and GFR with renal outcomes, we performed an observational study. A total of 3231 type 2 diabetic patients were included in this study between 2003 and 2005. There were 1249 women and the mean age was 59 ± 12 years. The renal endpoints were defined as the initiation of renal replacement therapy (RRT) or 50% reduction from the baseline of estimated GFR (eGFR). At baseline, 669 (20.7%) patients had eGFR <60 mL/min per 1.73 m(2) and 1134 (35.1%) had albuminuria. During the mean follow-up period of 5.9 ± 1.6 years, 107 patients initiated RRT. A 50% reduction of eGFR from the baseline value was found in 279 patients. None of the normoalbuminuric subjects with or without reduced eGFR required RRT during the observational period (P < 0.01). Compared to normoalbuminuria patients with eGFR ≥60 mL/min per 1.73 m(2) at baseline, the group of normoalbuminuria patients with reduced eGFR had a 2.5-fold risk of developing the renal endpoints, (95% confidence interval (CI)...Continue Reading

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Citations

Feb 7, 2016·Journal of Clinical Pharmacy and Therapeutics·A N Isaacs, A Vincent
Dec 1, 2017·Frontiers in Pharmacology·Hiroki EsakiHitomi Teramachi
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Jun 11, 2020·Journal of Advanced Research·Richard SaoudAyad A Jaffa

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