Albuminuria Increases All-Cause Mortality in Japanese Patients with Type 2 Diabetes Mellitus

Journal of Clinical Medicine
Hitomi MiyakeToshitsugu Sugimoto

Abstract

Previous studies have reported that diabetic kidney disease is associated with cardiovascular events and death. Little is known about the independent association of albuminuria and estimated glomerular filtration rate (eGFR), with mortality in Asian patients with type 2 diabetes mellitus (T2DM) without renal failure. We conducted a historical cohort study to clarify this issue in Japanese patients with T2DM. In this study, we recruited 385 patients with T2DM, who never had chronic renal failure (eGFR < 30 mL/min/1.73 m² at baseline) and malignant diseases. With the end point of all-cause mortality, Cox regression analysis was performed. During the observational period of 7 years, 54 patients died. Cox regression analysis adjusted for confounding factors such as age, duration of diabetes, body mass index, and HbA1c, and showed that urinary albumin level was significantly associated with the mortality [hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.03⁻1.70 per standard deviation (SD) increase, p = 0.031]. After additional adjustment for eGFR, the association remained significant (HR = 1.32, 95% CI = 1.02⁻1.70 per SD increase, p = 0.033). On the other hand, eGFR was not associated with the mortality. The present study ...Continue Reading

References

Feb 9, 2012·Clinical Chemistry·Michael A Ferguson, Sushrut S Waikar
Jan 31, 2013·Journal of the American Society of Nephrology : JASN·Maryam AfkarianIan H de Boer
Oct 18, 2013·Clinical and Experimental Nephrology·Takashi WadaUNKNOWN Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
May 27, 2014·European Journal of Preventive Cardiology·Cynthia C LimCharumathi Sabanayagam
Sep 25, 2014·Diabetes Care·Katherine R TuttleMark E Molitch
Oct 29, 2015·The New England Journal of Medicine·Mauro TancrediMarcus Lind
May 1, 2015·Kidney Diseases·Yasuhiko Tomino, Tomohito Gohda

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Methods Mentioned

BETA
urine collection

Software Mentioned

StatView

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