Albuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patients

Diabetologia
G N ThomasK S Wong

Abstract

Albuminuria has been reported to be a marker of cardiovascular risk factors and disease morbidity and mortality, but its relationship with intracerebral atherosclerotic disease is less clear. The aim of this study was to investigate the association between albuminuria and intracranial and extracranial vascular involvement in Chinese Type 2 diabetic patients. The anthropometric and fasting biochemical measurements of 966 Type 2 diabetic patients with normoalbuminuria (55.6%), microalbuminuria (27.7%) or macroalbuminuria (16.7%) were compared. The prevalence of microvascular and macrovascular disease and middle cerebral artery (MCA) stenosis, measured by transcranial Doppler ultrasound, were also compared between the groups. Albuminuria was closely associated with a range of adverse parameters, including high BP, dyslipidaemia, smoking and adiposity (all p<0.01). The prevalence of microvascular disease (retinopathy p<0.001) and macrovascular disease (peripheral vascular disease p=0.012, myocardial infarction, p=0.004, MCA stenosis p<0.001) increased significantly with increasing levels of albuminuria. Albuminuria was also found to be an independent predictor of microvascular and macrovascular disease. Albuminuria was an independe...Continue Reading

References

Nov 15, 1991·American Journal of Epidemiology·J HeG Q He
Jan 1, 1984·Ophthalmology·R KleinS E Moss
Dec 1, 1995·Stroke; a Journal of Cerebral Circulation·J HeP K Whelton
May 1, 1994·Current Opinion in Nephrology and Hypertension·C E Mogensen, P L Poulsen
Nov 14, 1997·Diabetes Care·J C Chan, C S Cockram
Aug 18, 2001·BMJ : British Medical Journal·T H LamR Peto
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen

❮ Previous
Next ❯

Citations

Oct 12, 2007·BMC Family Practice·Fatma Al-Maskari, Mohammed El-Sadig
Nov 20, 2012·Diabetes & Metabolic Syndrome·Salwa Selim Ibrahim Abougalambou, Ayman Selim Abougalambou
Mar 28, 2012·Advances in Chronic Kidney Disease·Bancha SatirapojSharon G Adler
Jun 17, 2005·Diabetes/metabolism Research and Reviews
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
Sep 30, 2006·Diabetes Research and Clinical Practice·Ritsuko YoshikawaHirofumi Makino
Jul 19, 2011·Atherosclerosis·R S RosensonP M Dodson
Dec 13, 2017·Journal of Human Hypertension·Paula Moreira da CostaElizabeth Silaid Muxfeldt
Oct 12, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Lingling XuYingshan Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.