Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster.

The Journal of Antibiotics
Chunshuai HuangChangsheng Zhang

Abstract

Heterologous expression of the fluostatin biosynthetic gene cluster from the marine-derived Micromonospora rosaria SCSIO N160 in Streptomyces albus J1074 led to the isolation of a novel isoindolequinone albumycin (1) and a known isoquinolinequinone mansouramycin A (2). The structure of 1 was elucidated on the basis of detailed 1D and 2D NMR spectroscopic analysis. Mansouramycin A (2) is active against methicillin-resistant Staphylococcus aureus ATCC 43300, with a MIC of 8 μg ml-1, while albumycin (1) displayed negligible antibacterial activities. This study represents another example of activation of secondary metabolites that are non-relevant to the heterologously introduced biosynthetic gene cluster in a bacterial host.

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Citations

Feb 27, 2020·Chemistry & Biodiversity·Sisi QiPeng Sun
Sep 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kaixiang TaoZhiyang Feng
Feb 12, 2021·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jan 15, 2021·Biochemical and Biophysical Research Communications·Shumao ChaiZhiyang Feng
Oct 8, 2021·Organic & Biomolecular Chemistry·Bidhan Chandra DeChangsheng Zhang

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