Alcohol abuse exaggerates autonomic dysfunction in chronic liver disease

Scandinavian Journal of Gastroenterology
S LindgrenG Sundkvist

Abstract

Advanced chronic liver disease is characterized by peripheral arterial vasodilation and increased plasma catecholamine concentrations. These haemodynamic alterations may reflect impaired vascular responsiveness due to autonomic nerve dysfunction. Three established non-invasive tests based on the heart reactions to deep breathing (expiratory/inspiratory (E/I) ratio) and to tilt (acceleration and brake indices) were used to evaluate age-related autonomic nerve function in 27 patients with chronic alcoholic and non-alcoholic liver disease. Liver function was estimated by demethylating capacity. The results were compared with a control group consisting of 56 healthy individuals. Overall, 12 patients (52%) had autonomic neuropathy (10 of 13 (77%) patients with alcoholic and 2 of 14 (14%) with non-alcoholic liver disease). Variance analysis showed that the age-corrected E/I ratio, but not the acceleration and brake indices, was significantly decreased compared with controls both in patients with alcoholic and non-alcoholic liver disease, indicating vagal nerve dysfunction (P < 0.0001 and 0.0133, respectively). The decrease in E/I ratio was also significantly more pronounced (-1.77 (0.62) (median (interquartile range)) versus 0.76 (0....Continue Reading

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Citations

Jan 8, 1999·Journal of the Neurological Sciences·M W AgelinkE Klieser
Sep 10, 2003·Transplantation Proceedings·J Pérez-PeñaG Clemente
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Sep 15, 2020·Muscle & Nerve·Divpreet KaurPaola Sandroni

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