Alcohol alters luteinizing hormone secretion in immature female rhesus monkeys by a hypothalamic action

Endocrinology
Gregory A DissenW L Dees

Abstract

We determined whether the effect of alcohol (ALC) to suppress LH secretion in immature female monkeys is due to a hypothalamic or pituitary site of action. Beginning at 20 months of age, four monkeys received a single intragastric dose of ALC (2.4 g/kg), and four monkeys received an equal volume of a saline/sucrose solution daily until they were 36 months old. For the hypothalamic response test, two basal samples (3.5 ml) were collected at 15-min intervals via the saphenous vein, and then N-methyl-D-L-aspartic acid (NMA; 20 mg/kg) was given iv and four more blood samples collected. Three weeks later, this protocol was repeated except LH-releasing hormone (LHRH) (5 microg/kg) was used to test pituitary responsiveness. NMA or LHRH was administered 3 h after the ALC. After the pituitary challenge, each monkey was ovariectomized and 6 wk later, implanted with an indwelling subclavian vein catheter. Blood samples were drawn every 10 min for 8 h to assess effects of ALC on post-ovariectomy LH levels and the profile of LH pulsatile secretion. The hypothalamic challenge showed NMA stimulated LH release in control monkeys, an action that was blocked by ALC. The pituitary challenge revealed that LHRH stimulated LH release equally well in...Continue Reading

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Citations

Jun 21, 2005·Alcohol·Jian-Ching RenMary Ann Emanuele
Aug 17, 2011·International Journal of Environmental Research and Public Health·Vinod K SrivastavaW Les Dees
Nov 27, 2015·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaWilliam L Dees
Jun 13, 2009·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaW Les Dees
Sep 2, 2009·Alcoholism, Clinical and Experimental Research·W Les DeesJill K Hiney
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Melissa HermanCatherine Rivier
Mar 5, 2014·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaWilliam L Dees
Apr 25, 2018·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaWilliam L Dees
Nov 13, 2019·Journal of Neuroendocrinology·William L DeesVinod K Srivastava
Sep 16, 2021·Alcoholism, Clinical and Experimental Research·William L DeesVinod K Srivastava

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