Alcohol alters rat adrenomedullary function and stress response

Annals of the New York Academy of Sciences
P Patterson-BuckendahlR Kvetnansky

Abstract

Most alcohol researchers do not address the effects of intoxication on the sympatho-adrenomedullary system response to stressful situations. We previously determined that rats consuming nearly 9 g ethanol (EtOH) per kg body weight per day in liquid diet form for 1 week increased adrenal gene expression of enzymes for catecholamine synthesis that was further elevated by acute IMMO. We hypothesized that the response to chronic mild stressors would also be altered after consumption of lower concentrations of EtOH in drinking water. Two experiments were conducted: 10% w/v for 4 weeks or 6% w/v for 7 weeks +/- wire mesh restraint (WMR). These were compared with ad libitum (adlib) and pair-fed control rats. Adrenal gene expression of catecholamine synthesizing enzymes was assayed. Tyrosine hydroxylase gene expression was elevated 80% to 90% by alcohol consumption in both experiments (P < 0.001) compared with adlib control rats. Dopamine betab-hydroxylase and phenylethanolamine-N-methyl transferase gene expressions were unaffected by 10% alcohol (P > 0.05) but were increased by 6% alcohol (P < 0.01). WMR decreased already elevated gene expression of all three enzymes. Pair feeding to 6% EtOH drinkers also increased gene expression for...Continue Reading

References

Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·L A Pohorecky
Feb 1, 1990·Alcoholism, Clinical and Experimental Research·I N MeffordM Linnoila
Jan 1, 1974·Pharmacology·L A PohoreckyH A Berkeley
Mar 1, 1984·Alcoholism, Clinical and Experimental Research·J BrickM N Adams
Mar 1, 1983·Journal of Studies on Alcohol·R HannonM Casey
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·G B GlavinR Murison
Sep 1, 1993·Journal of Studies on Alcohol. Supplement·R Gustafson
Jan 1, 1997·Psychopharmacology·A Herz
Jun 1, 1997·Psychopharmacology·A M van Erp, K A Miczek
Jul 21, 1998·Annals of the New York Academy of Sciences·R Kvetnanský, E L Sabban
Mar 1, 1996·Alcohol and Alcoholism. Supplement·P De Witte
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Dena DavidsonRobert Swift
Feb 27, 2003·Alcoholism, Clinical and Experimental Research·Peter R GiancolaBrian M Quigley

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Citations

Sep 6, 2005·Biological & Pharmaceutical Bulletin·Sew-Fen LeuBu-Miin Huang
Sep 12, 2008·The European Journal of Neuroscience·Olayinka A DinaJon D Levine
Jan 6, 2009·Annals of the New York Academy of Sciences·Patricia Patterson-BuckendahlRichard Kvetnanský
May 23, 2006·Alcohol·Patricia Patterson-BuckendahlRichard Kvetnansky
May 22, 2007·Stress : the International Journal on the Biology of Stress·P Patterson-BuckendahlR Kvetnansky
Aug 31, 2017·Cellular and Molecular Neurobiology·Patricia Patterson-BuckendahlLarissa A Pohorecky

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