Alcohol and breast cancer tumor subtypes in a Spanish Cohort

SpringerPlus
Manuela Gago-DomínguezMaria Elena Martinez

Abstract

Although alcohol intake is an established risk factor for overall breast cancer, few studies have looked at the relationship between alcohol use and breast cancer risk by the four major subtypes of breast cancer and very few data exist in the alcohol-breast cancer relationship in Spanish women. A population-based case-control study was conducted in Galicia, Spain. A total of 1766 women diagnosed with invasive breast cancer between 1997 and 2014 and 833 controls participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics were collected. We examined the alcohol-breast cancer association according to the major breast cancer subtypes [hormone-receptor-positive, HER2-negative (luminal A); hormone-receptor-positive, HER2-positive (luminal B); hormone-receptor-negative, HER2-negative (TNBC); and hormone-receptor-negative, HER2-positive (HER2 overexpressing)] as well as grade and morphology in Spanish women. With the exception of HER2 overexpressing, the risk of all subtypes of breast cancer significantly increased with increasing alcohol intake. The association was similar for hormonal receptor positive breast cancer, i.e., luminal A and luminal B breast cancer (odds ratio, OR ...Continue Reading

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May 1, 2018·International Journal of Cancer. Journal International Du Cancer·Michelle L BagliaChristopher I Li
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May 19, 2021·Scientific Reports·Manuela Gago-DominguezJ Esteban Castelao

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Methods Mentioned

BETA
hormone replacement therapy

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Stata

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