PMID: 7580819Sep 1, 1995Paper

Alcohol and drug problems: a multivariate behavioural genetic analysis of co-morbidity

Addiction
K L JangP A Vernon

Abstract

Multivariate biometrical genetic analyses of self-report questionnaire items assessing problem alcohol and drug use were performed on data obtained from a sample of 438 volunteer twin pairs (236 monozygotic twin pairs, 247 dizygotic twin pairs). Additive genetic influences were moderate for all alcohol abuse items (21-46%), frequency of drug use (32%) and illicit drug use (32%). Prescribed drug use and debilitating drug use were largely environmentally determined (86% and 94%, respectively). The influence of environmental factors that influence all members of a family to the same degree (shared family environment) on each item was generally small (0-20%), whereas the influence of environmental factors unique to each family member (non-shared environment) comprised over half of the total variance on all items. Genetic factor analyses identified three uncorrelated common genetic factors. The first genetic factor appears to represent problems associated with alcohol and drug use, such as the inability to fulfil obligations at home, work or school. The second genetic factor is more specific to drug use and represents a general liability towards drug use, illicit or otherwise. The third genetic factor is specific to the alcohol use ...Continue Reading

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Citations

May 24, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·William G IaconoMatt McGue
Dec 28, 2000·Addictive Behaviors·K R Merikangas, S Avenevoli
Dec 5, 1998·Drug and Alcohol Dependence·M B van den BreeR W Pickens
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Dec 13, 2005·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lynn R Webster, Rebecca M Webster
Jan 11, 2005·Journal of Drug Education·Johanna D BirckmayerKaren B Friend
Jul 16, 2005·The American Journal on Addictions·Katherine Anne ComtoisTracy Simpson
May 16, 2006·Addiction·Arpana Agrawal, Michael T Lynskey
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Sep 12, 2017·Health Services Research and Managerial Epidemiology·Maneesh SharmaAshley Brenton
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K S KendlerM C Neale

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