Abstract
Multivariate biometrical genetic analyses of self-report questionnaire items assessing problem alcohol and drug use were performed on data obtained from a sample of 438 volunteer twin pairs (236 monozygotic twin pairs, 247 dizygotic twin pairs). Additive genetic influences were moderate for all alcohol abuse items (21-46%), frequency of drug use (32%) and illicit drug use (32%). Prescribed drug use and debilitating drug use were largely environmentally determined (86% and 94%, respectively). The influence of environmental factors that influence all members of a family to the same degree (shared family environment) on each item was generally small (0-20%), whereas the influence of environmental factors unique to each family member (non-shared environment) comprised over half of the total variance on all items. Genetic factor analyses identified three uncorrelated common genetic factors. The first genetic factor appears to represent problems associated with alcohol and drug use, such as the inability to fulfil obligations at home, work or school. The second genetic factor is more specific to drug use and represents a general liability towards drug use, illicit or otherwise. The third genetic factor is specific to the alcohol use ...Continue Reading
References
Jul 1, 1976·Journal of Biosocial Science·J Kasriel, L Eaves
Jan 1, 1992·Comprehensive Psychiatry·C ChenH R Conte
May 1, 1992·Journal of the Experimental Analysis of Behavior·W L Palya
Mar 1, 1990·Journal of Personality·R Plomin, J R Nesselroade
Aug 1, 1990·Journal of Abnormal Psychology·D S KossonJ P Newman
Sep 1, 1990·Behavior Genetics·J J McArdle, H H Goldsmith
Jun 15, 1990·Biological Psychiatry·W M GroveD T Lykken
Aug 1, 1987·Alcoholism, Clinical and Experimental Research·J KaprioR J Rose
May 1, 1987·Archives of General Psychiatry·K S KendlerL J Eaves
Jul 1, 1987·Behavior Genetics·D T LykkenA Tellegen
Jan 1, 1987·Journal of Studies on Alcohol·R J CadoretT W O'Gorman
Oct 1, 1984·American Journal of Medical Genetics·B DallapiccolaP Cristalli
Apr 1, 1983·Child Development·R B McCall
Mar 1, 1994·Journal of Studies on Alcohol·C A PrescottL J Eaves
Dec 1, 1993·The American Journal of Psychiatry·W J LivesleyP A Vernon
Citations
Apr 20, 2006·Behavior Genetics·Arpana AgrawalDanielle M Dick
May 24, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·William G IaconoMatt McGue
Dec 28, 2000·Addictive Behaviors·K R Merikangas, S Avenevoli
Dec 5, 1998·Drug and Alcohol Dependence·M B van den BreeR W Pickens
Mar 7, 1998·Addiction·K L JangP A Vernon
Jul 8, 1998·The Journal of Nervous and Mental Disease·K L JangW J Livesley
Dec 13, 2005·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lynn R Webster, Rebecca M Webster
Jan 11, 2005·Journal of Drug Education·Johanna D BirckmayerKaren B Friend
Jul 16, 2005·The American Journal on Addictions·Katherine Anne ComtoisTracy Simpson
Sep 30, 2008·Addiction·Jaime DerringerWilliam G Iacono
May 16, 2006·Addiction·Arpana Agrawal, Michael T Lynskey
May 23, 2006·Addictive Behaviors·Alexandre A TodorovKathleen Keenan Bucholz
Oct 31, 2000·American Journal of Medical Genetics·L M KarkowskiK S Kendler
Sep 12, 2017·Health Services Research and Managerial Epidemiology·Maneesh SharmaAshley Brenton
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K S KendlerM C Neale