Alcohol and upper gastrointestinal tract cancer: the role of local acetaldehyde production

Addiction Biology
N Homann

Abstract

Alcohol is, together with tobacco smoke, the main cause for upper GI tract cancer in industrialized countries. However, the tumour-promoting effects of alcohol intake are poorly understood and alcohol itself is not carcinogenic in the animal model. There is increasing evidence that alcohol metabolism, rather than the alcohol itself, generates carcinogenic and cell-toxic compounds. Acetaldehyde, first metabolite of ethanol, is highly toxic, mutagenic and carcinogenic. Polymorphisms in the genes coding for enzymes responsible for acetaldehyde accumulation and detoxification have been associated with an increased cancer risk. Acetaldehyde can also be produced in the mucosa and by the physiological microflora. This review summarizes the scientific evidence that alcohol intake leads to a local production of acetaldehyde. It describes the role of the oral microflora, the mucosa and the salivary glands in this process and shows that local acetaldehyde production from ethanol may contribute to the carcinogenesis of alcohol intake in the upper GI tract.

References

Apr 1, 1978·Gut·S E Kaufman, M D Kaye
Jan 1, 1979·Clinical and Experimental Pharmacology & Physiology·A W Jones
Dec 1, 1977·Journal of the National Cancer Institute·S GrahamS Fischman
Oct 1, 1976·Cancer·E L WynderM Mushinski
Jul 1, 1992·European Journal of Cancer. Part B, Oral Oncology·J R MarshallD West
Jan 1, 1992·Human Genetics·H W GoeddeR Lisker
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F ParazziniS Franceschi
Aug 31, 1990·Science·S M Cohen, L B Ellwein
Jan 1, 1990·Environmental and Molecular Mutagenesis·S M He, B Lambert
Sep 5, 1990·Journal of the National Cancer Institute·S FranceschiC La Vecchia
Sep 15, 1990·International Journal of Cancer. Journal International Du Cancer·R TalaminiC La Vecchia
Sep 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberT Worner
Jan 1, 1988·Annual Review of Nutrition·H K Seitz, U A Simanowski
Mar 1, 1988·Journal of Clinical Psychology·M P CareyS A Maisto
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HoernerC S Lieber
Jul 20, 1988·Journal of the National Cancer Institute·D Albanes, M Winick
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W F Bosron, T K Li
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·H MaierH K Seitz
Oct 1, 1986·Alcoholism, Clinical and Experimental Research·H MiyakawaC S Lieber
Oct 15, 1986·Cancer·R G Ziegler
Nov 15, 1984·International Journal of Cancer. Journal International Du Cancer·J M ElwoodS M Jackson
Oct 15, 1983·International Journal of Cancer. Journal International Du Cancer·A J Tuyns
Sep 1, 1983·Scandinavian Journal of Gastroenterology·J A Salo
Aug 1, 1994·Clinical Otolaryngology and Allied Sciences·T BundgaardO Elbrønd
Apr 1, 1994·Alcoholism, Clinical and Experimental Research·H MaierI A Born
Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·J HuX Xu
May 5, 1993·Journal of the National Cancer Institute·S K NgE L Wynder
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·S J YinS C Lee
Jun 1, 1993·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H MaierW D Heller
Oct 1, 1996·Alcoholism, Clinical and Experimental Research·K JokelainenM Salaspuro
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·K W Singletary

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Citations

Dec 13, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Claire Infante-Rivard, Mariam El-Zein
May 20, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·L SunN Homann
May 18, 2005·Alcoholism, Clinical and Experimental Research·Leimin SunNils Homann
Jun 20, 2015·BioMed Research International·Jeniffer Dantas FerreiraSergio Koifman
Sep 24, 2004·Rapid Communications in Mass Spectrometry : RCM·Kornél NagyKároly Vékey
May 29, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wojciech Jelski, Maciej Szmitkowski
Sep 10, 2014·Nature Reviews. Microbiology·Petra LouisHarry J Flint
Apr 3, 2003·Rapid Communications in Mass Spectrometry : RCM·David SmithAlicia El Haj
Jan 8, 2011·Journal of Experimental & Clinical Cancer Research : CR·Dirk W Lachenmeier, Yulia B Monakhova
Feb 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine E GarnerNorman M Ratcliffe
Jan 15, 2014·Journal of Breath Research·B de Lacy CostelloN M Ratcliffe
Nov 19, 2014·Seminars in Immunopathology·Naoko Ohtani
Apr 11, 2014·International Journal of Cancer. Journal International Du Cancer·Sen-Tien TsaiJeffrey S Chang
Aug 4, 2015·Angewandte Chemie·Yoav Y BrozaHossam Haick
Jan 27, 2016·World Journal of Gastroenterology : WJG·Johan GagnièreMathilde Bonnet
May 21, 2003·Critical Reviews in Clinical Laboratory Sciences·Mikko P Salaspuro
Aug 31, 2017·Scientific Reports·Cheng-Chih HuangJeffrey S Chang
Apr 29, 2020·Journal of Oral Microbiology·Abdrazak AmerGary P Moran
Jun 16, 2018·World Journal of Gastroenterology : WJG·Romain VillégerMathilde Bonnet
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·A W L BayciR Keidan
Jan 25, 2020·Molecular Medicine Reports·Rui-Ying WangXiao-Bing Shen
Jul 10, 2020·BMC Microbiology·Esam HalboubNezar Noor Al-Hebshi
Jun 17, 2020·Archives of Toxicology·Andrea HartwigGerhard Eisenbrand
Oct 25, 2011·The International Journal of Biological Markers·Jelena RadojicicDemetrios A Spandidos
Mar 25, 2021·Journal of Breath Research·Natalia DrabińskaBen De Lacy Costello
Nov 26, 2008·Cancer Cell International·Wojciech FilipiakJakob Troppmair
Nov 10, 2009·Oral Oncology·Xabier Marichalar-MendiaJose M Aguirre-Urizar

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