Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis

Drug and Alcohol Review
Jürgen RehmMichael Roerecke

Abstract

Alcohol is an established risk factor for liver cirrhosis. It remains unclear, however, whether this relationship follows a continuous dose-response pattern or has a threshold. Also, the influences of sex and end-point (i.e. mortality vs. morbidity) on the association are not known. To address these questions and to provide a quantitative assessment of the association between alcohol intake and risk of liver cirrhosis, we conducted a systematic review and meta-analysis of cohort and case-control studies. Studies were identified by a literature search of Ovid MEDLINE, EMBASE, Web of Science, CINAHL, PsychINFO, ETOH and Google Scholar from January 1980 to January 2008 and by searching the references of retrieved articles. Studies were included if quantifiable information on risk and related confidence intervals with respect to at least three different levels of average alcohol intake were reported. Both categorical and continuous meta-analytic techniques were used to model the dose-response relationship. Seventeen studies met the inclusion criteria. We found some indications for threshold effects. Alcohol consumption had a significantly larger impact on mortality of liver cirrhosis compared with morbidity. Also, the same amount o...Continue Reading

References

Jun 1, 1978·International Journal of Epidemiology·G PequignotJ L Berta
Feb 1, 1975·Experimental and Molecular Pathology·L H Augenlicht, T S Argyris
Jun 1, 1992·American Journal of Epidemiology·S Greenland, M P Longnecker
Dec 22, 1988·The New England Journal of Medicine·C S Lieber
Nov 1, 1988·Preventive Medicine·L GarfinkelS D Stellman
Feb 1, 1987·American Journal of Epidemiology·T Gordon, J T Doyle
Dec 1, 1986·International Journal of Epidemiology·S KonoM Kuratsune
Mar 1, 1984·International Journal of Epidemiology·A J Tuyns, G Pequignot
Jul 1, 1984·American Journal of Epidemiology·T Gordon, W B Kannel
Aug 1, 1981·Annals of Internal Medicine·A L KlatskyA B Siegelaub
Feb 1, 1980·The American Journal of Medicine·W C BlackwelderY Palesch
Oct 19, 1995·The New England Journal of Medicine·E J SijbrandsR G Westendorp
May 11, 1995·The New England Journal of Medicine·C S FuchsB Rosner
Aug 1, 1995·European Journal of Epidemiology·M M Morales Suárez-VarelaA Llopis González
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeckerG Jensen
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Dec 11, 1997·The New England Journal of Medicine·M J ThunR Doll
Dec 17, 1997·Scandinavian Journal of Gastroenterology·G CorraoF Di Orio
Aug 27, 1998·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G CorraoP Torchio
Jan 1, 1996·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·K S MillerJ Kunz
Aug 18, 2001·European Addiction Research·E GutjahrJ Rehm
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ulrik BeckerThorkild I A Sørensen
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Nov 5, 2002·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Stéphanie PelletierBertrand Nalpas
Sep 11, 2003·American Journal of Epidemiology·Arthur L KlatskyHarald Kipp
Sep 13, 2003·European Addiction Research·Jürgen RehmDavid Jernigan
Apr 7, 2004·Preventive Medicine·Giovanni CorraoCarlo La Vecchia
Jul 13, 2004·Journal of Hepatology·Mads Kamper-JørgensenUlrik Becker
Oct 1, 2004·Biological Research·Morten GrønbaekUlrik Becker
Mar 2, 2006·Digestive Diseases·Benjamin TaylorGerhard Gmel
Oct 19, 2007·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Knut StokkelandRolf Hultcrantz
Nov 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Samir Zakhari, Ting-Kai Li
Feb 5, 2008·Drug and Alcohol Dependence·Deborah A DawsonBridget F Grant
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Susanne May, Carol Bigelow
Aug 15, 2008·American Journal of Epidemiology·Arthur L Klatsky
Dec 5, 2008·Alcoholism, Clinical and Experimental Research·Gyongyi Szabo, Pranoti Mandrekar

❮ Previous
Next ❯

Citations

Apr 6, 2011·International Journal of Public Health·Kevin D ShieldJürgen Rehm
Sep 15, 2010·European Archives of Psychiatry and Clinical Neuroscience·Manfred M FichterUwe C Fischer
Aug 7, 2012·Current Atherosclerosis Reports·Michael Roerecke, Jürgen Rehm
Dec 16, 2010·American Journal of Epidemiology·Michael Roerecke, Jürgen Rehm
Mar 28, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J Rehm, M Roerecke
Jul 9, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Alvaro Castillo-CarnigliaPaulina Pino
Mar 16, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V BagnardiC La Vecchia
Mar 6, 2013·European Journal of Public Health·Sylvie GuérinCatherine Hill
Dec 18, 2013·BMJ : British Medical Journal·Graham JohnsonPatrick Davies
Jan 1, 2010·Digestive Diseases·S BellentaniC Tiribelli
Dec 20, 2012·Therapeutic Advances in Chronic Disease·Helena Cortez-Pinto
Apr 19, 2011·BMC Medical Research Methodology·Gerrit GmelJürgen Rehm
Feb 8, 2014·PloS One·Astrid Ledgaard HolmFinn Diderichsen
Feb 10, 2012·Interdisciplinary Toxicology·Yuriy V SolodunDirk W Lachenmeier
Sep 21, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Heng JiangWilliam C Kerr
Feb 12, 2014·International Journal of Epidemiology·Michael Roerecke, Jürgen Rehm
Aug 8, 2014·Clinical Medicine : Journal of the Royal College of Physicians of London·Nick SheronMaria Thomas
Feb 2, 2013·Digestive Diseases and Sciences·Mutsumi TsuchishimaMikihiro Tsutsumi
Jan 6, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Dirk W LachenmeierJürgen Rehm
Jan 22, 2015·BMC Medicine·Alan D LopezCleusa P Ferri
Dec 29, 2015·International Journal of Clinical Practice·V RosatoM Persico
Dec 11, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Yan-Di XieLai Wei
Aug 11, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anam KhanFasiha Kanwal
Mar 24, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Elisa FrullantiCarlo Zocchetti
Dec 14, 2011·Journal of Substance Abuse Treatment·Betty Tai, A Thomas McLellan
Jan 19, 2011·The International Journal on Drug Policy·Dirk W LachenmeierJürgen Rehm
Oct 17, 2015·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Francesca L BeaudoinRoland C Merchant

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.