In 20 healthy male subjects faecal blood loss was measured by means of a chromium-51-labelled red blood cell technique. Mean daily faecal blood loss associated with unbuffered aspirin ingestion was significantly increased by alcohol in the 13 subjects studied. In seven others alcohol alone did not cause gastrointestinal bleeding. These findings suggest that alcohol may accentuate gastrointestinal blood loss associated with unbuffered aspirin ingestion.
Effect of other drugs and chemicals on the degradation of aspirin in vitro: possible extrapolation to in vivo metabolism of aspirin
Abnormal aspirin metabolism in patients with cirrhosis and its possible relationship to bleeding in cirrhotics
Antiprostaglandin synthetase activity of nonsteroidal anti-inflammatory drugs and gastrointestinal micro-bleeding: a comparison of flurbiprofen with benoxaprofen
Diflunisal versus aspirin: a comparative study of their effect of faecal blood loss, in the presence and absence of alcohol
Effects of aspirin and alcohol on platelet thromboxane synthesis and vascular prostacyclin synthesis
Local buccal mucosal effects of aspirin, indomethacin and isoxepac: their relationship to gastrointestinal damage
A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men
This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.