PMID: 8945078Nov 1, 1996Paper

Alcohol concentration determines the type of atrial arrhythmia induced in a porcine model of acute alcoholic intoxication

Pacing and Clinical Electrophysiology : PACE
M J AnadonJ L De Guevara

Abstract

Alcohol abuse has long been suspected clinically to cause paroxysmal atrial tachyarrhythmias. However, such a relationship has never been conclusively proven, partly due to the lack of experimental evidence. Although atrial fibrillation (AF) is the most common atrial arrhythmia attributed to acute alcoholic ingestion, atrial flutter has occasionally been noted. We analyzed the possible role of alcohol in initiation and/or maintenance of a variety of atrial tachyarrhythmias in a closed-chest porcine model. Nine pigs underwent nine endocardial right atrial stimulation protocols (RASP) at baseline and 17 RASPs after increasing doses of ethanol (first infusion 1,230 mg/kg, second infusion 870 mg/kg) by means of one multipolar catheter advanced under heavy sedation from the femoral vein. Each RASP included 1, 2, and 3 extrastimuli, and rapid pacing at 5 times diastolic threshold. Venous ethanol concentrations were measured (HPGC method) every 10 minutes and at the time of arrhythmia induction. Atrial tachyarrhythmias were induced in 4 of 9 baseline RASPs, and lasted for a mean of 21 seconds, and in 16 of 17 RASPs after alcohol lasting for a mean of 357 seconds. Only fibrillation was observed at the baseline RASP. The atrial tachyarr...Continue Reading

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Citations

Jan 11, 2001·Journal of Pharmacological and Toxicological Methods·G S Friedrichs
Sep 1, 2008·Seminars in Interventional Radiology·Sandeep VaidyaManrita Sidhu
Jun 1, 2006·Seminars in Interventional Radiology·José I BilbaoOctavio Cosín
Oct 26, 2013·Neuroimaging Clinics of North America·Joseph J GemmeteNeeraj Chaudhary
May 6, 2004·Journal of Vascular and Interventional Radiology : JVIR·Patricia E Burrows, Keira P Mason
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Jul 11, 2006·International Journal of Cardiology·Juan Benezet-Mazuecos, Adolfo de la Fuente
Feb 18, 2004·Journal of Korean Medical Science·Jeong-Jin LeeJie-Ae Kim
Nov 20, 2009·Journal of Cardiovascular Medicine·Anil George, Vincent M Figueredo
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Carlos E B BalbãoGuilherme Fenelon
Mar 22, 2019·Nature Reviews. Cardiology·Sebastian ClaussStefan Kääb
Oct 18, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yun Gi KimYoung-Hoon Kim
Oct 14, 2018·Current Cardiology Reports·Chrishan J NalliahJonathan M Kalman
Feb 15, 2003·Biological Research for Nursing·Joan A Masters, Joanne S Stevenson

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