Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Alcohol
Ana MotaMargarida Fonseca Cardoso

Abstract

Alcohol abuse is an important public health problem. In Portugal with a population of 10 millions of inhabitants, there are around 10% of alcoholics or excessive alcohol drinkers and 1% of chronically infected patients with hepatitis B virus (HBV). To examine the characteristics of patients with higher levels of alcohol consumption and to investigate the association between alcohol consumption and liver damage a total of 298 chronically infected individuals, with HBV genotyped and submitted to liver biopsy, were classified with Child's grading and separated by habits of alcohol intake, less and greater than 20g/day. No significant differences were observed about genotype but genotypes A and D were predominant in both of them. A higher percentage of males (P<.001) were observed in the group with alcohol intake above 20g/day, as well a lower proportion of patients with HBeAg negativity (P< or =.035). In this group, biochemistry parameters, such as alanine aminotransferase (P=.006), aspartate aminotransferase (P=.001), gamma-glutamyl transferase (P<.001) were elevated in a significantly higher proportion than in the other group. The analysis of hematological parameters showed significantly lower values of platelets (P=.042) and me...Continue Reading

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Citations

Oct 30, 2012·Clinics in Liver Disease·Angela C KimThien-Ly Doan
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yan-Di XieLai Wei
Feb 23, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Silvana Gama Florencio ChacháAna de Lourdes Candolo Martinelli
Nov 26, 2010·Revista de saúde pública·Ana MotaMargarida Fonseca Cardoso

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