Alcohol consumption and HIV disease progression: are they related?

Alcoholism, Clinical and Experimental Research
Jeffrey H SametKenneth A Freedberg

Abstract

The relationship between alcohol consumption and HIV disease progression has received limited attention in the era of highly active antiretroviral therapy (HAART). We assessed CD4 cell count, HIV RNA levels, and alcohol consumption in the past month, defined as none, moderate, and at risk, in 349 HIV-infected people with a history of alcohol problems. We investigated the relationship between alcohol consumption and HIV disease markers CD4 cell count and HIV RNA level, stratified by HAART use, using multivariable regression. No significant differences in CD4 cell count or HIV RNA level were found across the categories of alcohol consumption for patients who were not receiving HAART. However, among patients who were receiving HAART, log HIV RNA levels were significantly higher in those with moderate (2.17 copies/ml) and at-risk (2.73 copies/ml) alcohol use compared with none (1.73 copies/ml; p = 0.006). CD4 cell counts in those with moderate (368 cells/microl) and at-risk (360 cells/microl) alcohol use were lower than for subjects who reported none (426 cells/microl; p = 0.07). Among patients who have a history of alcohol problems and are receiving antiretroviral treatment, alcohol consumption was associated with higher HIV RNA l...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 4, 1989·BMJ : British Medical Journal·F J Dunne
Jul 1, 1985·The Journal of Nervous and Mental Disease·A T McLellanC P O'Brien
Oct 12, 1984·JAMA : the Journal of the American Medical Association·J A Ewing
Jul 1, 1984·Annals of Emergency Medicine·K A GibbR M Nowak
Aug 1, 1995·Journal of General Internal Medicine·F LefevreJ Glassroth
Apr 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C PachlB Irvine
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·R T Cook
May 16, 1998·American Journal of Public Health·M F FlemingK Johnson
Jun 24, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L J EldredR D Moore
Jun 27, 1998·JAMA : the Journal of the American Medical Association·M A Wainberg, G Friedland
Jan 27, 2000·JAMA : the Journal of the American Medical Association·C C CarpenterP A Volberding
Feb 1, 2000·The American Journal of Medicine·E R Schiff
Jul 6, 2000·Annals of Internal Medicine·D L PatersonN Singh
Sep 15, 2001·Journal of General Internal Medicine·B J TurnerS A Bozzette
Aug 9, 2002·AIDS Research and Human Retroviruses·Thomas F KresinaLaura W Cheever

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Citations

Apr 13, 2006·AIDS and Behavior·Cynthia H ChuangJeffrey H Samet
Jun 10, 2010·AIDS and Behavior·Katherine TassiopoulosGeorge R Seage
Jul 30, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Buffie Longmire-AvitalJeffrey T Parsons
Jul 9, 2005·Drug and Alcohol Dependence·Evgeny M KrupitskyJeffrey H Samet
Mar 2, 2005·AIDS Care·D J BriefUNKNOWN HIV/AIDS Treatment Adherence, Health Outcomes and Cost Study Group
May 21, 2010·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·Anne Pithey, Charles Parry
Mar 17, 2004·AIDS Research and Human Retroviruses·Jeffrey H SametKenneth A Freedberg
May 21, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·María José Míguez-BurbanoRobert M Malow
Aug 2, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey H SametRichard Saitz
May 3, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Evan S WuSteven D Douglas
Aug 3, 2006·Journal of General Internal Medicine·Michael K Paasche-OrlowJeffrey H Samet
Oct 24, 2009·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Shiela M Strauss, David M Rindskopf
Sep 21, 2007·Epidemiologic Perspectives & Innovations : EP+I·Mariel M FinucaneNicholas J Horton
May 8, 2007·Violence and Victims·Cynthia H ChuangJeffrey H Samet
Jan 16, 2010·American Journal of Public Health·Rebecca L CollinsRobin Beckman
Dec 19, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Maria Patrizia CarrieriUNKNOWN ANRS CO8 APROCO-COPILOTE Study Group
Jan 17, 2014·AIDS Patient Care and STDs·Mari-Lynn DrainoniAlexander Y Walley
May 13, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Manuela G NeumanHelmut K Seitz
Jul 28, 2012·AIDS and Behavior·Robert L CookMardge H Cohen
Jan 15, 2016·Addiction Science & Clinical Practice·E Jennifer EdelmanDavid A Fiellin
Apr 27, 2010·Journal of Substance Abuse Treatment·Gavin H HarrisMark W Parrino
Nov 10, 2007·The Journal of the Association of Nurses in AIDS Care : JANAC·Constance R UpholdJorge P Parada
Mar 14, 2016·Drug and Alcohol Dependence·David S FestingerDavid S Metzger
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·R Scott BraithwaiteAmy C Justice

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