PMID: 9549000Apr 29, 1998Paper

Alcohol consumption and micronutrient intake as risk factors for liver cirrhosis: a case-control study. The Provincial Group for the study of Chronic Liver Disease

Annals of Epidemiology
G CorraoF Di Orio

Abstract

The purpose of this study was to assess the relationship of alcohol consumption and intake of 15 selected micronutrients with risk of liver cirrhosis. Data from a case-control study performed in 1989-1990 in central Italy involving 115 incident cases and 167 hospital controls were used. Cases and controls did not differ for mean daily intake of calories, carbohydrates, lipids, and proteins. Significant direct dose-response relationships between the intakes of vitamin A and iron and the risk cirrhosis were observed, while significant protective effects were obtained for the intakes of vitamins B2 (riboflavin) and B12. Different patterns of the joint effect of nutrients and alcohol were also observed. The intakes of vitamin A and iron were significantly associated with the risk of cirrhosis in lifetime teetotalers (odds ratios (OR) and 95% coincidence intervals (CI) of 33.6 (1.2-979.9) and 37.9 (1.8-819.4) for higher intake of vitamin A and iron, respectively) and in consumers of < 50 g/day of alcohol (vitamin A: OR 45.0; 95% CI, (2.6-774.6); iron: OR, 73.6; 95% CI, 4.3-999). The OR associated with intakes of vitamins B2 (riboflavin) and B12 were not significant for the first two categories of alcohol use, while a higher intake o...Continue Reading

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Mar 24, 2004·Free Radical Biology & Medicine·Jose M Jimenez-Lopez, Arthur I Cederbaum
Sep 15, 2001·Annals of Epidemiology·G CorraoUNKNOWN Collaborative SIDECIR Group
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Feb 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ho-Young ParkInwook Choi
Sep 30, 2009·European Journal of Gastroenterology & Hepatology·Gabriella BekoAnna Blazovics
Aug 30, 2019·The American Journal of Gastroenterology·Michael RoereckeJürgen Rehm
Aug 24, 2017·Scandinavian Journal of Gastroenterology·Maria Inês CanhaPedro Figueiredo
Jun 21, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Nooshin HosseiniGyongyi Szabo

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