Alcohol consumption and rectal tumor mutations and epigenetic changes.

Diseases of the Colon and Rectum
Martha L SlatteryWade S Samowitz

Abstract

An association between alcohol and rectal cancer has been reported in the epidemiological literature. In this study we further explore the association by examining specific tumor markers with alcohol consumption as well as types of alcoholic beverages consumed. We assessed alcohol consumption with CpG Island Methylator Phenotype, TP53, and KRAS2 mutations in incident rectal cancer cases and compared them with population-based controls. We evaluated type, long-term, and recent alcohol consumption. We observed a trend toward increasing risk of CpG Island Methylator Phenotype positive tumors and long-term alcohol consumption. In contrast, after adjusting for total alcohol intake, recent high beer consumption significantly increased the odds of having a TP53 mutation compared with those who did not drink beer (odds ratio, 1.97; 95% CI 1.24, 3.12). We observed a nonstatistically significant reduced risk of a TP53 mutation among those who drank wine (in particular, red wine) vs nonconsumers of wine. The association between TP53 mutations and recent beer consumption was strongest for transversion mutations. These data suggest that both alcohol and specific constituents of alcoholic beverages contribute to rectal cancer risk among uniq...Continue Reading

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Citations

Jun 8, 2012·Cancer Causes & Control : CCC·Jeanette A StingoneAndrew F Olshan
May 19, 2012·Diseases of the Colon and Rectum·Niki KontouDemosthenes Panagiotakos
Dec 31, 2011·Journal of Experimental & Clinical Cancer Research : CR·Yan-Wei LinJing-Yuan Fang
Nov 8, 2011·Biochimica Et Biophysica Acta·Laura A E HughesManon van Engeland
Dec 17, 2014·Epigenetics : Official Journal of the DNA Methylation Society·V L J WhitehallB A Leggett
Jun 26, 2015·Alcoholism, Clinical and Experimental Research·DawnKylee S KlarichMee Young Hong
Apr 5, 2015·Digestive Diseases and Sciences·Masakazu Yashiro
Jan 20, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·X C LiK X Chen

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