Alcohol consumption and risk for Parkinson's disease: a systematic review and meta-analysis

Journal of Neurology
Félix Javier Jiménez-JiménezJosé A G Agúndez

Abstract

The possibility that alcohol consumption should be considered as a "protective factor" for Parkinson's disease (PD) has been suggested by several case-control studies. However, other case-control studies and data from prospective longitudinal cohort studies have been inconclusive. We carried out a systematic review which included all the eligible studies published on PD risk related with alcohol consumption, and conducted a meta-analysis according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The systematic review was performed using two databases, and the meta-analysis of the eligible studies with the software Meta-Disc1.1.1. Heterogeneity between studies was tested with the Q-statistic. The meta-analysis included 26 eligible retrospective case-control studies (8798 PD patients, 15,699 controls) and 5 prospective longitudinal cohort studies (2404 PD patients, 600,592 controls) on alcohol consumption and PD. In retrospective case-control studies the frequency of PD patients never drinkers was higher and the frequency of heavy + moderate drinkers was lower [diagnostic OR (95% CI) 1.33(1.20-1.48) and 0.74(0.64-0.85)], respectively, when compared to healthy controls. In contrast, in...Continue Reading

References

Oct 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·F J Jiménez-JiménezS Giménez-Roldan
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 1, 1982·Annals of Neurology·A E LangJ D Parkes
Aug 1, 1981·American Journal of Epidemiology·D G HaackJ A Turbek
Mar 1, 1994·Acta Neurologica Scandinavica·A MoranoM A Antolín
Feb 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·F HoshiS Kawamura
Mar 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·R MayeuxY Stern
Jun 15, 1994·American Journal of Epidemiology·A GrandinettiD MacEachern
Sep 1, 1993·Neurology·J P HubbleW C Koller
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·P A FallA K Granérus
Jan 28, 1999·Neurology·J M GorellE L Peterson
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·A M KuopioU K Rinne
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·S BuervenichL Olson
May 18, 2001·Neuroscience Letters·E K TanT Ashizawa
May 19, 2001·Neuroepidemiology·A Paganini-Hill
Sep 28, 2001·Journal of the Neurological Sciences·M BehariR M Pandey
Apr 12, 2002·American Journal of Epidemiology·Harvey CheckowayPhillip D Swanson
Jul 26, 2002·Clinical Neurology and Neurosurgery·C H TsaiC S Lu
Aug 2, 2003·Annals of Neurology·Miguel A HernánAlberto Ascherio
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 7, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Jean-Philippe GalanaudChristophe Tzourio
Nov 3, 2004·Annals of Neurology·Karin WirdefeldtNancy L Pedersen
Feb 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·A H EvansA J Lees
Jun 7, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Lianna Ishihara, Carol Brayne
Jul 14, 2006·BMC Medical Research Methodology·Javier ZamoraArri Coomarasamy
Mar 3, 2007·Occupational and Environmental Medicine·F D DickUNKNOWN Geoparkinson study group
Sep 18, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L Ishihara-PaulP G Surtees
Dec 2, 2008·Journal of Agromedicine·Amanpreet S DhillonSara Shepherd
Dec 1, 2005·Nutrition Research Reviews·Lianna Ishihara, Carol Brayne
Feb 7, 2009·Parkinsonism & Related Disorders·Laura BrighinaDemetrius M Maraganore
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Alessandra NicolettiMario Zappia
Nov 9, 2010·BMC Neurology·Wakaba FukushimaUNKNOWN Fukuoka Kinki Parkinson's Disease Study Group
Nov 16, 2010·Behavioural Brain Research·Andrea Carmine BelinDagmar Galter
Nov 15, 2011·Behavioural Brain Research·Anna AnvretAndrea Carmine Belin
Jun 2, 2012·Molecular Neurodegeneration·Leonid MolochnikovSilvia A Mandel
Jun 21, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Natalia PalaciosAlberto A Ascherio
Oct 17, 2012·Annals of Neurology·Alastair J NoyceAnette Schrag

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Citations

Sep 5, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Judy PotashkinConnie Marras
May 2, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Susan PetersRoel Vermeulen
Nov 30, 2018·Journal of Neurology·Elena García-MartínFélix Javier Jiménez-Jiménez
Aug 21, 2020·Neurology·Samantha MolsberryAlberto Ascherio
Jan 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tekla Maria KylkilahtiIben Lundgaard
Apr 6, 2021·Journal of Parkinson's Disease·Yancong ChenIrene X Y Wu
Jun 3, 2021·Journal of Personalized Medicine·Pedro AyusoJosé María Ladero
Jun 29, 2021·Frontiers in Molecular Biosciences·Iskra AraujoDanielle Gulick
Jul 29, 2021·Clinical Parkinsonism & Related Disorders·Susan Searles NielsenBrad A Racette
Jul 20, 2021·Journal of Parkinson's Disease·Karl HeilbronUNKNOWN 23andMe Research Team

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