Alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases: a prospective study and meta-analysis.

PloS One
Dagmar DroganCornelia Weikert

Abstract

First, to investigate and compare associations between alcohol consumption and variants in alcohol dehydrogenase (ADH) genes with incidence of cardiovascular diseases (CVD) in a large German cohort. Second, to quantitatively summarize available evidence of prospective studies on polymorphisms in ADH1B and ADH1C and CVD-risk. We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort including a randomly drawn subcohort (n = 2175) and incident cases of myocardial infarction (MI; n = 230) or stroke (n = 208). Mean follow-up time was 8.2±2.2 years. The association between alcohol consumption, ADH1B or ADH1C genotypes, and CVD-risk was assessed using Cox proportional hazards regression. Additionally, we report results on associations of variants in ADH1B and ADH1C with ischemic heart disease and stroke in the context of a meta-analysis of previously published prospective studies published up to November 2011. Compared to individuals who drank >0 to 6 g alcohol/d, we observed a reduced risk of MI among females consuming >12 g alcohol/d (HR = 0.31; 95% CI: 0.10-0.97) and among males consuming >24 to 60 g/d (HR = 0.57; 95% CI: 0.33-0.98) or >60 g alcohol/d (HR ...Continue Reading

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Citations

Jul 24, 2012·Human Molecular Genetics·Carlos CruchagaAlison M Goate
Jan 17, 2013·Alcohol·Gudrun HøisethJørg Mørland
Jun 24, 2015·Nature Reviews. Cardiology·Joaquim Fernández-Solà
Jun 19, 2015·International Journal of Epidemiology·Stephen BurgessGeorge Davey Smith
Apr 30, 2016·International Journal of Cardiology·Zhao LiAbraham Marria Roselle
Oct 16, 2018·Alcoholism, Clinical and Experimental Research·Howard J Edenberg, Jeanette N McClintick
Feb 6, 2019·Food Research International·Thulile NdlovuOluwafemi J Caleb

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Methods Mentioned

BETA
genotyping
Assay

Software Mentioned

meta
Funnel Plot
EMBASE
SAS
R

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