Abstract
Understanding the role of modest alcohol consumption in patients with non-alcohol induced fatty liver disease (NAFLD) remains a significant challenge, with no clear guidance on counselling regarding alcohol use. Conventionally, the strong association of alcohol excess and development of complications related to chronic liver disease, including hepatocellular carcinoma, has led practitioners to advocate complete abstinence to those with NAFLD. New evidence published in this issue of the Red Journal challenges the historic paradigm by showing that modest, non-binge wine consumption (<70 g/week) associates with significantly lower risk of advanced hepatic fibrosis on biopsy compared with complete abstinence across a well-characterised single centre cohort of nearly 200 patients with NAFLD.
References
Jul 1, 1995·Epidemiology·C La VecchiaR Pagano
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeckerG Jensen
Jul 5, 2001·Gastroenterology·J B DixonP E O'Brien
May 4, 2006·BMC Public Health·Kenneth J MukamalLuc Djoussé
May 19, 2007·The American Journal of Gastroenterology·Ayako SuzukiKeith Lindor
May 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winston DunnJeffrey B Schwimmer
Nov 20, 2008·Scandinavian Journal of Gastroenterology·Mattias EkstedtStergios Kechagias
Feb 6, 2009·European Journal of Gastroenterology & Hepatology·Helma P CotrimStephen Caldwell
Jun 25, 2009·The American Journal of Gastroenterology·Toshiaki GunjiAkio Urabe
Mar 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mustafa S AschaNizar N Zein
Mar 13, 2010·BMJ : British Medical Journal·Carole L HartGeorge Davey Smith
Apr 15, 2010·Seminars in Thrombosis and Hemostasis·Giuseppe LippiGiovanni Targher
Dec 2, 2010·Alimentary Pharmacology & Therapeutics·A MoriyaK Yamamoto
Apr 24, 2012·Journal of Hepatology·Winston DunnJeffrey B Schwimmer
Jan 29, 2013·American Journal of Epidemiology·Rohit LoombaChien-Jen Chen
Jul 3, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Hellan K KwonHari S Conjeevaram
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Jan 19, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Veeral H AjmeraStephen A Harrison
Jul 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniArun J Sanyal
Aug 15, 2017·Gastroenterology·Lisa B VanWagnerJuned Siddique
Nov 23, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fredrik ÅbergAntti Jula