Alcohol consumption is not protective for systemic lupus erythematosus.

Annals of the Rheumatic Diseases
J WangT E McAlindon

Abstract

Several studies have suggested that alcohol drinking is protective for the development and progression of systemic lupus erythematosus (SLE). However, a protopathic bias might also explain this apparent association. Our objective was to investigate the association between alcohol consumption and incidence of SLE in a data set that has information on both current and pre-diagnostic alcohol consumption. We performed an Internet-based case-control study of SLE. Cases were diagnosed within 5 years of the study and met > or =4 American College of Rheumatology criteria for SLE. The control participants were tightly matched to cases on demographic and socio-economic characteristics using a propensity score. Participants completed an online exposure assessment. We used conditional logistic regression analyses to test the association of current and pre-diagnostic alcohol consumption with SLE. The sample comprised 114 cases with SLE and 228 matched controls. Current drinking (>2 days per week) was inversely associated with SLE (OR 0.35, 95% CI 0.13 to 0.98). Having more than two drinks per day was also inversely associated with SLE (OR 0.41, 95% CI 0.18 to 0.93). However, alcohol consumption before SLE diagnosis was not associated with t...Continue Reading

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Citations

Dec 30, 2009·Clinical Rheumatology·Hai-Feng PanDong-Qing Ye
Sep 13, 2014·International Journal of Molecular Sciences·Anselm Mak, Sen Hee Tay
Sep 17, 2013·Dental Clinics of North America·Giulio Fortuna, Michael T Brennan
Jun 15, 2011·Best Practice & Research. Clinical Rheumatology·Sean O'Neill, Ricard Cervera
Nov 3, 2015·Seminars in Arthritis and Rheumatism·Maria Dolores Rodríguez HuertaUNKNOWN Spanish SLE CPG Development Group
Mar 5, 2014·Arthritis & Rheumatology·Lamiae Grimaldi-BensoudaUNKNOWN PGRx Lupus Study Group
Mar 16, 2016·Journal of Clinical Epidemiology·Andrea Arfè, Giovanni Corrao
May 17, 2012·The Journal of Rheumatology·Chikako KiyoharaUNKNOWN Kyushu Sapporo SLE (KYSS) Study Group
Aug 26, 2016·Nature Reviews. Rheumatology·Erin E CarterAnn E Clarke
Jul 19, 2016·Current Opinion in Rheumatology·Medha Barbhaiya, Karen H Costenbader

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