Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults

Annals of Epidemiology
Lei GaoH Brenner

Abstract

Moderate alcohol consumption has been suggested to facilitate the elimination of Helicobacter pylori infection as the result of its antibacterial effect. We aimed to assess the associations of current and lifetime alcohol consumption as well as serum gamma-glutamyltransferase (GGT), an established biomarker of alcohol consumption, with H. pylori infection in a large population-based study. In the baseline examination of the ESTHER study, serological measurements of antibodies against H. pylori and GGT measurements were taken in 9733 subjects ages 50 to 74 years. Information on lifestyle factors and medical history were obtained by self-administered standardized questionnaire. A significant inverse association, in dose-response manner, was observed between both current and lifetime alcohol consumption and H. pylori seropositivity. The estimates based on lifetime consumption were more pronounced than the results for current consumption, and such inverse associations were found both for men and women. Stronger relations were observed for those who only drank wine or mixed drinkers compare with those who only drank beer. Furthermore, there was a significant inverse dose-response relationship between serum GGT levels and H. pylori s...Continue Reading

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Citations

Jan 7, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Huan-Lin ChenMing-Jong Bair
Nov 26, 2010·Orvosi hetilap·György Miklós Buzás
Nov 26, 2014·European Journal of Epidemiology·Mangesh A Thorat, Jack Cuzick
Aug 16, 2016·The Kaohsiung Journal of Medical Sciences·Cheng-En TsaiSeng-Kee Chuah
Feb 18, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jianguang JiKristina Sundquist
Feb 3, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shih-Wei Lai

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