PMID: 8597391Dec 29, 1995Paper

Alcohol, corticosteroids, energy utilization, and hippocampal endangerment

Annals of the New York Academy of Sciences
R L EskayC Hamelink

Abstract

The cellular weakening or cytoxic consequences of CAC are intertwined in the most fundamental sense with energy intake, production, storage, and mobilization. The impact of CAC on the HPA axis to increase GCs makes this energy regulatory hormone along with pancreatic hormones a potential major player in the site-specific organ pathologies associated with CAC. Although little is known about the mechanism of CAC neurotoxicity, the hippocampal endangerment model which relies heavily on the cellular weakening, site-specific effect of continuous or chronic, intermittent (withdrawal, binge drinking) elevation of GCs, even less is known about the mechanism of neurotoxicity of activating the ethanol-inducible CYP2E1 system. It is likely that components of both models contribute to the site-specific, CNS neurotoxicity associated with CAC, but this remains largely unresolved.

References

Jan 1, 1978·Neuropsychologia·D W Walker, B E Hunter
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·C S Lieber
Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G S Wand, A S Dobs
Nov 1, 1990·Neuroendocrinology·R L Spencer, B S McEwen
Dec 1, 1990·Biochemical Pharmacology·B S McEwen, E Gould
Jan 1, 1990·The American Review of Respiratory Disease·R J HoppN M Nair
Mar 31, 1989·Science·D M LovingerF F Weight
Jan 1, 1989·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·B Keane, B E Leonard
Jul 1, 1988·Nutrition Reviews·C S Lieber
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Apr 30, 1973·Annals of the New York Academy of Sciences·P E Stokes
Mar 1, 1971·Psychosomatic Medicine·J H MendelsonN K Mello
Mar 1, 1971·Psychosomatic Medicine·M OgataE Majchrowicz
Jan 1, 1984·The Medical Clinics of North America·R H Noth, R M Walter
Jan 1, 1981·Annual Review of Medicine·T J Cicero
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·D W WalkerW C Abraham
Jan 1, 1982·British Medical Bulletin·M Y Morgan
Nov 30, 1993·Behavioural Brain Research·R M Sapolsky
Nov 1, 1993·Alcohol·H Tsukamoto, S W French
Oct 1, 1993·Frontiers in Neuroendocrinology·M F DallmanM Smith
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M WarnerJ A Gustafsson
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Warner, J A Gustafsson
Jan 22, 1993·Brain Research·H K AnandatheerthavaradaV Ravindranath
Mar 1, 1993·Trends in Endocrinology and Metabolism : TEM·M F Dallman
Oct 1, 1992·Journal of Neuroendocrinology·M F DallmanC S Cascio

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Citations

Feb 22, 2011·Alcoholism, Clinical and Experimental Research·Mohammad SametiGeorge Fein
Sep 17, 2004·Biochemical and Biophysical Research Communications·John J Haddad
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Bryon AdinoffMark J Williams
Jun 21, 1997·Annals of the New York Academy of Sciences·R K Pitman
Jan 5, 2001·Alcoholism, Clinical and Experimental Research·D D RasmussenC W Wilkinson
May 10, 2005·The Journal of Pharmacology and Experimental Therapeutics·Carol HamelinkRobert L Eskay

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