Alcohol decreases serum osteocalcin in a dose-dependent way in normal subjects

Calcified Tissue International
H K NielsenC Hansen

Abstract

The acute effect of 25 and 50 g of alcohol on the variation in serum osteocalcin, a specific and sensitive marker of bone formation, and on serum cortisol and serum parathyroid hormone (PTH)(1-84) was calculated in 6 normal young adults. They were studied during three periods, each lasting from 4 p.m.-7:30 a.m. Alcohol was ingested between 4:15 and 5 p.m. during period two and three. Blood was taken at 4 p.m. and every 15 minutes from 4:30 til 6 p.m., followed by hourly sampling until 12 p.m. The last blood sample was taken after an overnight fast at 7:30 a.m. Initial and end values before and after alcohol ingestion did not differ significantly from control values. Repeated measures analysis of variance showed that 50 g of ethanol decreased serum osteocalcin significantly (P less than 0.02) and increased serum cortisol (P less than 0.05) during the 4-12 p.m. interval. The interaction of 50 g of ethanol on the variation in serum osteocalcin was already significant during the first 2 hours (P less than 0.02), where no significant effect on serum cortisol could be detected. Although insignificant, the same pattern was observed after 25 g of alcohol. There was no significant change in the variation of serum iPTH(1-84) during the 4...Continue Reading

References

Mar 1, 1978·Metabolism: Clinical and Experimental·J H ShanG A Williams
Jan 1, 1975·Zeitschrift für Rechtsmedizin. Journal of legal medicine·G Machata
Apr 1, 1985·Archives of Biochemistry and Biophysics·J R FarleyK H Lau
Sep 16, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·D E Cole, C M Gundberg
Jan 1, 1988·Calcified Tissue International·M Garcia-CarrascoL Miravet
Mar 1, 1988·Calcified Tissue International·R A MelickJ D Wark
Nov 1, 1988·The Journal of Clinical Endocrinology and Metabolism·H K NielsenL Mosekilde
Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·A R BrasierS R Nussbaum
Dec 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B L RiggsK G Mann
Apr 1, 1985·The Journal of Clinical Endocrinology and Metabolism·C M GundbergJ F Rosen
Mar 1, 1971·Psychosomatic Medicine·J H MendelsonN K Mello
Mar 1, 1971·Psychosomatic Medicine·M OgataE Majchrowicz
Dec 1, 1983·The American Journal of Medicine·E SeemanB L Riggs
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P A Price, S K Nishimoto

❮ Previous
Next ❯

Citations

Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M SchnitzlerH J Robson
Jun 16, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K S HoweR T Turner
Jan 27, 2010·Journal of Bone and Mineral Metabolism·Christine M SchnitzlerRoy Shires
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·L S Kidder, R T Turner
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A P HermannL Mosekilde
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R T TurnerJ D Sibonga
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F J Gallego-RojoD Rodrigo-Moreno
Mar 15, 2016·Alcoholism, Clinical and Experimental Research·Gino W GaddiniUrszula T Iwaniec
Aug 1, 1993·Annals of Medicine·K Laitinen, M Välimäki
May 18, 2018·Biological & Pharmaceutical Bulletin·Chikako ShimizuToshitaka Nabeshima
Oct 2, 1998·Alcoholism, Clinical and Experimental Research·H M PerryH M Perry
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·N GiulianiM Pedrazzoni
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·H M PerryH M Perry
Apr 1, 1997·Alcoholism, Clinical and Experimental Research·H W SampsonB DeFee
Dec 31, 2005·Alcoholism, Clinical and Experimental Research·Dennis A Chakkalakal
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·H W SampsonB DeFee
Oct 1, 1996·Alcoholism, Clinical and Experimental Research·K KeiverJ Weinberg
May 24, 2001·Alcoholism, Clinical and Experimental Research·R T TurnerJ D Sibonga
Dec 5, 2000·Alcoholism, Clinical and Experimental Research·R T Turner
Jun 1, 1993·Alcoholism, Clinical and Experimental Research·D D BikleR Recker
May 1, 1997·Alcoholism, Clinical and Experimental Research·R F Klein
Jan 1, 1991·Critical Reviews in Clinical Laboratory Sciences·M J Power, P F Fottrell
Aug 19, 2018·Alcoholism, Clinical and Experimental Research·Ursula Föger-SamwaldWolfgang Sipos
Nov 10, 2020·Alcoholism, Clinical and Experimental Research·Cristiane do Socorro Ferraz MaiaRafael Rodrigues Lima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.