Alcohol dependence: the impact of cognitive behaviour therapy with or without naltrexone on subjective health status

The Australian and New Zealand Journal of Psychiatry
G F FeeneyAnnie McPherson

Abstract

To examine the health-related quality of life of alcohol-dependent patients across a 12-week cognitive behaviour treatment (CBT) program and identify whether the patient selection of the anticraving medication naltrexone further enhanced these outcomes. One hundred and thirty-six consecutive alcohol-dependent subjects voluntarily participated and were offered naltrexone, of which 73 (54%) participants declined medication. A matched design was used. Of the 136 subjects, 86 (43 naltrexone and CBT; 43 CBT only) could be individually matched (blind to outcome measures) for gender, age, prior alcohol detoxification and dependence severity. Measures of health status and mental health wellbeing included the Rand Corporation Medical Outcomes Short Form 36 Health Survey (SF-36) and the General Health Questionnaire (GHQ-28). Pre-treatment, all had SF-36 and GHQ-28 scores markedly below national norms. Post-treatment, significant improvement in seven of the eight SF-36 subscales and all of the GHQ-28 subscales occurred, approximating national normative levels. Patients in the CBT + naltrexone group were significantly more likely to have increased days abstinent (p=0.002) and to complete the program abstinent (p=0.051). The adjunctive use ...Continue Reading

References

Nov 1, 1992·Archives of General Psychiatry·J R VolpicelliC P O'Brien
Nov 1, 1992·Archives of General Psychiatry·S S O'MalleyB Rounsaville
Nov 1, 1989·Psychological Medicine·J OrmelR Giel
Aug 18, 1989·JAMA : the Journal of the American Medical Association·A L StewartJ E Ware
Sep 1, 1972·The American Journal of Psychiatry·A D PokornyH B Kaplan
Oct 1, 1993·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J A WelshC B Kaplan
Nov 1, 1995·Journal of Studies on Alcohol·C TimkoB S Moos
Aug 1, 1996·Australian and New Zealand Journal of Public Health·E K WatsonI Ring
Apr 1, 1997·Australian and New Zealand Journal of Public Health·R Taylor
Aug 1, 1997·Alcoholism, Clinical and Experimental Research·R J VolkA R Cass
Sep 3, 1999·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J H FosterT J Peters
Sep 27, 2000·Journal of Clinical Epidemiology·M A SprangersH C de Haes
Apr 11, 2001·Lancet·P Fayers, K Bjordal
Sep 5, 2001·The Australian and New Zealand Journal of Psychiatry·G F FeeneyA McPherson
Nov 13, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C Streeton, G Whelan
Dec 14, 2001·The New England Journal of Medicine·J H KrystalUNKNOWN Veterans Affairs Naltrexone Cooperative Study 425 Group
Mar 27, 2004·Nursing Philosophy : an International Journal for Healthcare Professionals·Margaret J Connor

❮ Previous
Next ❯

Citations

Dec 2, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Deborah A DawsonBridget F Grant
Feb 5, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Faika ZanjaniDavid W Oslin
Aug 31, 2012·Epilepsy Research and Treatment·Najam-Us Sahar
Jan 5, 2006·Acta Psychiatrica Scandinavica·L Sher
Nov 3, 2010·Australian and New Zealand Journal of Public Health·Jennie ConnorKypros Kypri
Jun 28, 2019·The American Journal of Drug and Alcohol Abuse·Davies AdeloyeIsaac F Adewole
May 10, 2013·Harvard Review of Psychiatry·Chio UgochukwuWaguih William Ishak
Apr 26, 2018·Ciência & saúde coletiva·Mariana Oliveira GuimarãesPatrícia Maria Pereira de Araújo Zarzar
Dec 5, 2008·Alcoholism, Clinical and Experimental Research·Helen M PettinatiStephanie S O'Malley
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein

❮ Previous
Next ❯

Methods Mentioned

BETA
cognitive behavioural therapy

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.