Alcohol devaluation has dissociable effects on distinct components of alcohol behaviour

Psychopharmacology
Abigail K RoseLee Hogarth

Abstract

Substance-related behaviour is often viewed as an appetitive behaviour, motivated by the reinforcing effects of the drug. However, there are various indices of substance motivation (e.g. attentional bias, behavioural economic demand, craving) and it is unclear how these are related or whether they play an important role in all types of substance-related behaviour. (1) To determine the effect of alcohol devaluation on several indices of alcohol motivation and goal-directed and cue-elicited alcohol behaviour. (2) To investigate which components of motivation mediate any effect of devaluation on behaviour. Sixty-two social drinkers gave baseline measures of alcohol craving, behavioural economic demand and choice for alcohol vs. soft drink. Participants tasted alcohol which was either unadulterated (control) or adulterated with a bitter solution (devaluation) before craving and demand were measured again. Alcohol choice was assessed in several phases: extinction (evaluating goal-directed behaviour), in the presence of drink cues (Pavlovian-to-instrumental transfer (PIT, cue-elicited behaviour)), and reacquisition. Attentional bias (AB) was measured by tracking eye movements towards the drink cues during novel PIT trials where both ...Continue Reading

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Citations

Nov 14, 2019·Psychological Research·Justin MahlbergAhmed A Moustafa
Jul 27, 2018·Psychopharmacology·Justin C StricklandWilliam W Stoops
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Roberto U CofresíThomas M Piasecki
Apr 29, 2019·Drug and Alcohol Dependence·Justin C StricklandWilliam W Stoops
May 27, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Joseph L AlcornCraig R Rush
Aug 8, 2021·Alcohol·Chloe N Shields, Christina M Gremel

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pharmacotherapies

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