Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice.

ELife
L. S. HwaThomas L Kash

Abstract

Maladaptive responses to stress are a hallmark of alcohol use disorder, but the mechanisms that underlie this are not well characterized. Here, we show that kappa opioid receptor signaling in the bed nucleus of the stria terminalis (BNST) is a critical molecular substrate underlying abnormal stress responses to predator odor following heavy alcohol drinking. Exposure to predator odor during protracted withdrawal from intermittent alcohol drinking resulted in enhanced prefrontal cortex (PFC)-driven excitation of prodynorphin-containing neurons in the BNST. Furthermore, deletion of prodynorphin in the BNST and chemogenetic inhibition of the PFC-BNST pathway restored abnormal responses to predator odor in alcohol-exposed mice. These findings suggest that increased corticolimbic drive may promote abnormal stress behavioral responses to predator odor during protracted withdrawal. Various nodes of this PFC-BNST dynorphin-related circuit may serve as potential targets for potential therapeutic mediation as well as biomarkers of negative responses to stress following heavy alcohol drinking.

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Citations

Jun 7, 2021·Behavioural Brain Research·Maria M Ortiz-JuzaJose Rodriguez-Romaguera
Jun 12, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nigel C DaoNicole A Crowley

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Software Mentioned

ImageJ
Image Analysis Wizard
BORIS ( Behavioral Observation Research Interactive Software
Ethovision
Ethovision XT13
GraphPad Prism
Zeiss Zen 2 Blue Edition
BORIS
Clampfit
Zen Blue

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