Alcohol drinking and cigarette smoking in relation to risk of active tuberculosis: prospective cohort study

BMJ Open Respiratory Research
Avril Z SohWoon-Puay Koh

Abstract

Heavy alcohol consumption increases the risk of active tuberculosis (TB). However, the relation between lower levels of alcohol intake and TB risk remains unclear. We aimed to evaluate the association between alcohol intake and risk of active TB and assess whether the associations were modified by smoking status, which is another risk factor for active TB. The Singapore Chinese Health Study is a prospective cohort of 63 257 adults aged 45-74 years recruited from 1993 to 1998. Information on alcohol intake and smoking history was collected at recruitment. Active TB cases were identified via linkage with National TB Notification Registry. During a mean follow-up of 16.8 years, 1249 incident cases of active TB were identified. Among non-smokers, compared with total abstinence, participants who had monthly to weekly intake of alcohol had reduced TB risk (HR 0.70, 95% CI 0.55 to 0.89), but this reduction in risk with low-dose drinking was not observed among current smokers (HR 0.96, 95% CI 0.77 to 1.18; p for interaction=0.02). Comparatively, drinking 2+ drinks daily was associated with increased TB risk among current smokers (HR 1.51, 95% CI 1.11 to 2.05). This increased risk was not observed among non-smokers (HR 0.93, 95% CI 0.49...Continue Reading

Citations

Aug 1, 2019·PloS One·Beena Elizabeth ThomasUNKNOWN CTRIUMPH-RePORT India Study
Dec 13, 2018·Nature Communications·January WeinerUNKNOWN GC6-74 consortium
Feb 17, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y MaLiang Li
Jan 1, 2021·The American Journal of Clinical Nutrition·Ting-Ting GengWoon-Puay Koh
Nov 22, 2020·Journal of the American Medical Directors Association·Yan-Feng ZhouWoon-Puay Koh
May 20, 2021·The Journal of Infectious Diseases·María B ArriagaBruno B Andrade
Dec 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Huiqi LiWoon-Puay Koh

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