PMID: 15252294Jul 15, 2004Paper

Alcohol effects during acamprosate treatment: a dose-response study in humans

Alcoholism, Clinical and Experimental Research
Susan M BrasserElisabeth J Houtsmuller

Abstract

Acamprosate (calcium acetyl homotaurinate) reduces alcohol intake in animals and increases abstinence rates in alcohol-dependent persons. Acamprosate's mechanism of action, however, remains poorly understood. In order to examine whether acamprosate/alcohol interactions contribute to acamprosate's efficacy, the present double-blind, placebo-controlled human laboratory study examined effects of acamprosate on the pharmacokinetics and subjective, psychomotor, and physiological effects of alcohol in heavy drinkers. In a six-week within-subject design, participants were maintained on acamprosate (0, 2, and 4 g, p.o., double-blind, in counterbalanced order) for 11 days at each dose. Physiological, subjective, and psychomotor measures were collected daily during each dosing cycle. During each acamprosate dose condition, subjects were challenged with 0, 0.5, and 1.0 g/kg ethanol (p.o., counterbalanced order) during three separate laboratory sessions. Subjective, physiological, and psychomotor effects of alcohol, and breath alcohol levels were collected at baseline and at 30-min intervals for a 3-hr post-administration period. Acamprosate alone did not substantially affect subjective, physiological, or psychomotor performance measures. ...Continue Reading

References

Jan 1, 1992·Acta Psychiatrica Scandinavica. Supplementum·B Johansson
Jan 1, 1992·Acta Psychiatrica Scandinavica. Supplementum·E N Petersen
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·M DaoustP Durbin
Jan 1, 1991·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·M GewissP De Witte
Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J P LhuintreF Boismare
Jun 1, 1990·Journal of Clinical Psychopharmacology·T KirkR R Griffiths
Nov 1, 1984·Pharmacology, Biochemistry, and Behavior·F BoismareJ Durlach
Aug 1, 1983·Archives of General Psychiatry·R R GriffithsI Liebson
Sep 1, 1995·Addiction·J Littleton
Oct 1, 1994·The American Journal of Psychiatry·R M SwiftH Hsuing
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·C S MartinR M Swift
Aug 1, 1996·Archives of General Psychiatry·H SassW Zieglgänsberger
Jun 3, 1996·European Journal of Pharmacology·R SpanagelW Zieglgänsberger
Jun 3, 1996·European Journal of Pharmacology·R SpanagelW Zieglgänsberger
Jun 3, 1996·European Journal of Pharmacology·R SpanagelW Hundt
Dec 12, 1996·European Journal of Pharmacology·J PutzkeW Zieglgänsberger
Aug 1, 1997·Alcoholism, Clinical and Experimental Research·S M HölterR Spanagel
Jul 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·I PelcP Lehert
Jan 16, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C J HeyserG F Koob
Dec 5, 1998·Clinical Pharmacokinetics·S SaivinG Houin
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·D DavidsonR Swift
Mar 25, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E McCaulL J Cheskin
Apr 20, 2000·European Journal of Pharmacology·R L Popp, D M Lovinger
Apr 6, 2001·Alcoholism, Clinical and Experimental Research·C L CzachowskiH H Samson
May 1, 2002·Alcoholism, Clinical and Experimental Research·George F KoobGeorge R Siggins
Oct 10, 2002·Psychopharmacology·Etienne QuertemontPhilippe De Witte
Oct 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Barbara J MasonMichael G Boyeson

❮ Previous
Next ❯

Citations

Sep 3, 2013·Psychopharmacology·Andrew HolmesJohn H Krystal
Nov 18, 2011·Inflammopharmacology·Z SternbergF E Munschauer
Jan 11, 2014·Psychopharmacology·Stefan JongenAnnemiek Vermeeren
Feb 19, 2010·Expert Opinion on Drug Metabolism & Toxicology·William Klugh KennedyRyan M Carnahan
Jun 7, 2005·Expert Opinion on Emerging Drugs·Raye Z LittenMark Egli
Jan 5, 2016·Alcoholism, Clinical and Experimental Research·Lara A RayDaniel J O Roche
Dec 11, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sargo AaltoHarry Scheinin
Jan 18, 2007·Fundamental & Clinical Pharmacology·Sophie Tambour, Etienne Quertemont
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Sionaldo Eduardo FerreiraMaria Lucia Oliveira de Souza-Formigoni
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Elizabeth RalevskiIsmene Petrakis
Jan 20, 2011·Alcoholism, Clinical and Experimental Research·David M PenetarScott E Lukas
Jan 3, 2013·British Journal of Clinical Pharmacology·Nicola J Kalk, Anne R Lingford-Hughes
Nov 22, 2005·Drug and Alcohol Dependence·Adam Bisaga, Suzette M Evans
Apr 16, 2008·Neurobiology of Learning and Memory·Danielle Gulick, Thomas J Gould
Jul 6, 2014·Frontiers in Behavioral Neuroscience·Regina A MangieriRueben A Gonzales
Jun 9, 2016·Behaviour Research and Therapy·Spencer Bujarski, Lara A Ray
Nov 23, 2006·Journal of Clinical Psychopharmacology·Ismene L Petrakis
May 12, 2018·Addiction Biology·Kassi L KosnickiScott T Kelley
Nov 18, 2015·World Journal of Gastroenterology : WJG·Randy LiangAijaz Ahmed
Aug 25, 2005·Clinical Therapeutics·Lisa A Boothby, Paul L Doering

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.