Alcohol effects on LH and FSH in ovariectomized female monkeys

Alcohol
N K MelloA S Skupny

Abstract

The acute effects of alcohol (2.5, 3.0, 3.5 g/kg) and sucrose control solution on basal levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were compared in recently and chronically ovariectomized female rhesus monkeys. Integrated plasma samples were collected at 20 min intervals for 3 hr before and 6 hr after nasogastric intubation of alcohol or isocaloric sucrose control solution. Baseline levels of LH and FSH were significantly higher in recently than in chronically ovariectomized females (p less than 0.001). Baseline LH pulse frequency was also significantly higher (p less than 0.001) in the recently ovariectomized group than in the chronically ovariectomized group (0.704 +/- 0.03 vs. 0.379 +/- 0.10 pulses/hr). FSH pulse frequency was equivalent in both groups (0.444 +/- 0.06 to 0.360 +/- 0.06 pulses/hr). After 2.5 g/kg of alcohol, peak blood alcohol levels were 243 to 256 mg/dl and LH decreased significantly (p less than 0.01) in both groups. After 3.0 g/kg alcohol, peak blood alcohol levels were 237 to 289 mg/dl, and basal LH levels (p less than 0.05) and LH pulse frequency (p less than 0.05) decreased significantly only in the recently ovariectomized group. After 3.5 g/kg of alcohol, peak blood alco...Continue Reading

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Citations

Apr 1, 1990·Alcoholism, Clinical and Experimental Research·M G SubramanianE L Abel
Feb 1, 1992·Alcoholism, Clinical and Experimental Research·M NyströmM Salaspuro
Oct 1, 1994·Alcoholism, Clinical and Experimental Research·P SillanaukeeK Seppä
Jan 23, 1998·Alcoholism, Clinical and Experimental Research·N LaPagliaN Emanuele
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·P SillanaukeeR Z Litten
Jun 13, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Birgitte AndersenPaul Kievit
Mar 14, 2020·Reproductive Biology and Endocrinology : RB&E·Cristina de AngelisRosario Pivonello

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