Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS-induced colitis

Journal of Leukocyte Biology
Abigail R CannonMashkoor A Choudhry

Abstract

Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammation, rectal bleeding, and dehydration. Interestingly, a widespread recommendation to IBD patients for avoidance of a flare period is "Don't Drink Alcohol" as recent work correlated alcohol consumption with increased GI symptoms in patients with IBD. Alcohol alone not only induces a systemic pro-inflammatory response, but can also be directly harmful to gut barrier integrity. However, how alcohol could result in the exacerbation of UC in both patients and murine models of colitis has yet to be elucidated. Therefore, we conducted a retrospective analysis of patients admitted for IBD with a documented history of alcohol use in conjunction with a newly developed mouse model of binge alcohol consumption following dextran sulfate sodium (DSS)-induced colitis. We found that alcohol negatively impacts clinical outcomes of patients with IBD, specifically increased intestinal infections, antibiotic injections, abdomen CT sca...Continue Reading

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Citations

Oct 7, 2019·Inflammatory Bowel Diseases·Mahesh KrishnaRichard Kellermayer
Jun 9, 2020·Addiction·Paul S Haber, Nicholas C Kortt
Sep 29, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah TalleyEdward M Campbell
Dec 14, 2018·Biomolecules·Niya L Morris, Samantha M Yeligar
May 15, 2021·Inflammatory Bowel Diseases·Bradley A WhiteSunanda Kane
Oct 14, 2021·Journal of Clinical Medicine·Paweł Kuźnicki, Katarzyna Neubauer
Oct 12, 2021·Molecular Nutrition & Food Research·Shiyu LiLavanya Reddivari
Dec 23, 2021·Food & Function·Li-Yang WeiYing Chen

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