Alcohol impairment of saccadic and smooth pursuit eye movements: impact of risk factors for alcohol dependence.

Psychopharmacology
Daniel J O Roche, Andrea C King

Abstract

While persons at risk for alcohol dependence by virtue of heavy drinking patterns or family history (FH) of alcohol use disorders have exhibited differential alcohol responses on a variety of measures, few studies have examined alcohol's effects on eye movements in these subgroups. The purpose of this study was to (1) conduct a placebo-controlled, dose-ranging study of alcohol's effects on eye movements and (2) examine the impact of these risk factors on oculomotor response to alcohol. A within-subject, double-blind laboratory study was conducted in N = 138 heavy (HD; n = 78) and light social drinkers (LD; n = 60) with self-reported positive (FH+) or negative (FH-) family history. Subjects participated in three laboratory sessions in which they consumed a beverage containing a high (0.8 g/kg) or low (0.4 g/kg) dose of alcohol or placebo. Smooth pursuit, pro-saccadic, and anti-saccadic eye movements were recorded before and at two intervals after alcohol consumption. Alcohol significantly impaired smooth pursuit gain and pro- and anti-saccade latency, velocity, and accuracy in a dose and time specific matter. HD and LD showed similar impairment on smooth pursuit gain and anti-saccade measures, but HD were less impaired in pro-sa...Continue Reading

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Citations

Sep 10, 2014·Human Brain Mapping·Inga MeyhöferUlrich Ettinger
Feb 22, 2012·Alcoholism, Clinical and Experimental Research·Emma ChildsHarriet de Wit
Sep 17, 2011·Alcoholism, Clinical and Experimental Research·Andrea C KingSandra Y Rueger
Oct 15, 2013·Alcoholism, Clinical and Experimental Research·Daniel J O RocheAndrea C King
Jun 8, 2012·Drug and Alcohol Dependence·Jessica Weafer, Mark T Fillmore
Aug 25, 2020·Psychopharmacology·Poppy WatsonMike E Le Pelley
Sep 4, 2019·Drug and Alcohol Dependence·Brook A ShiferawLuke A Downey
Mar 12, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Adam M McNeillDerek Heim

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