PMID: 9450680Feb 5, 1998Paper

Alcohol increases the expression of type 1, but not type 2 alpha corticotropin-releasing factor (CRF) receptor messenger ribonucleic acid in the rat hypothalamus

Brain Research. Molecular Brain Research
S Lee, C Rivier

Abstract

We investigated the ability of a moderately intoxicating dose of alcohol (3 g/kg, injected i.p. 3 h earlier) to up-regulate the genetic expression of CRF receptor type 1 (CRF-R1) and 2 (CRF-R2alpha) in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus as well as in the amygdala. The mRNA encoding CRF-R1 was not constitutively expressed in the PVN or the SON but was present in the amygdala. Alcohol selectively up-regulated CRF-R1 transcripts in the PVN. Basal levels of CRF-R2alpha transcripts were present in the limbic system and the ventromedial hypothalamic nucleus but were not altered by alcohol. We then determined whether the up-regulation of hypothalamic CRF-R1 mRNA levels was functionally connected to CRF-dependent pathways. We first showed that the i.c.v. injection of CRF significantly (P < 0.01) increased CRF-R1 but not CRF-R2alpha mRNA levels. We then injected the CRF antagonist, astressin, i.c.v. 30 min prior to alcohol, at a dose previously shown to completely block many CRF-dependent events in the brain, and found that it did not significantly interfere with-alcohol-induced gene expression of PVN CRF-R1. These results indicate that acute alcohol treatment selectively activates CRF-R1 ...Continue Reading

References

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Citations

Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Dec 22, 1999·Biological Psychiatry·T Steckler, F Holsboer
Oct 18, 2000·European Journal of Pharmacology·G N Smagin, A J Dunn
Nov 6, 2003·Regulatory Peptides·Daniel J Lodge, Andrew J Lawrence
Mar 31, 1999·Neurochemistry International·W Q DingC Alling
Jun 5, 2002·Alcoholism, Clinical and Experimental Research·Andrey E RyabininGeorge F Koob
Feb 16, 2012·The Journal of Pharmacology and Experimental Therapeutics·Raúl PastorTamara J Phillips
Aug 23, 2008·Endocrinology·Catherine L Rivier
Feb 26, 2016·Physiology & Behavior·Anne Q Fosnocht, Lisa A Briand
Apr 30, 2003·Journal of Neuroendocrinology·H JørgensenJ Warberg
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Raúl PastorTamara J Phillips
Nov 6, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samuel W CentanniDanny G Winder
Nov 8, 2016·Frontiers in Endocrinology·Isabel Marian Hartmann QuadrosCristiane Aparecida Favoretto

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