Alcohol-independent beneficial cardiometabolic profile of individuals with hyper-HDL cholesterolemia in Japanese men and women

Journal of Clinical Lipidology
Ichiro Wakabayashi, Takashi Daimon

Abstract

There is limited information on characterization of individuals with hyper-high-density lipoprotein (HDL) cholesterolemia. The purpose of this study was to investigate the cardiometabolic profile of individuals with hyper-HDL cholesterolemia in comparison with the profile of individuals with normo-HDL cholesterolemia. The subjects were Japanese men and women who had hyper-HDL cholesterolemia (≥100 mg/dL) and their control subjects who had normal HDL cholesterol levels (≥40 and <80 mg/dL) and were matched for age or age and alcohol consumption. The cardiometabolic profiles were compared between the hyper- and normo-HDL cholesterolemic groups. Both in men and women, body mass index, waist-to-height ratio, triglycerides, low-density lipoprotein cholesterol, and hemoglobin A1c were significantly lower in subjects with hyper-HDL cholesterolemia than in subjects with normo-HDL cholesterolemia, whereas systolic and diastolic blood pressure levels were not significantly different between the 2 groups. In generalized estimating equation with adjustment for smoking and regular exercise, odds ratios of the hyper- vs normo-HDL cholesterolemic groups were significantly lower than the reference level of 1.00 for high body mass index, high wa...Continue Reading

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Citations

Oct 13, 2021·Journal of Primary Care & Community Health·Satyajeet RoyKrystal Hunter

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