Alcohol-induced bone disease: impact of ethanol on osteoblast proliferation

Alcoholism, Clinical and Experimental Research
R F Klein

Abstract

The habitual consumption of even moderate quantities of alcohol (1 to 2 drinks/day) is clearly linked with reduced bone mass (osteopenia). Biochemical and histological evaluation of patients with alcoholic bone disease reveal a marked impairment in bone formation in the face of relatively normal bone resorption. Experiments using well-defined osteoblastic model systems indicate that the observed reductions in bone formation result from a direct, antiproliferative effect of ethanol on the osteoblast itself. As bone remodeling and mineralization are dependent on osteoblasts, it follows that the deleterious effect of alcohol on these cells would result in slowed bone formation, aberrant remodeling of skeletal tissue and, ultimately, osteopenia and fractures. The skeletal consequences of alcohol intake during adolescence, when the rapid skeletal growth ultimately responsible for achieving peak bone mass is occurring, may be especially harmful. The specific subcellular mechanisms whereby ethanol inhibits cell proliferation are, as yet, unknown. During the last few years, attention has shifted from nonspecific membrane perturbation effects to actions on certain signaling proteins. Specifically, there is increasing evidence that ethan...Continue Reading

References

Apr 6, 1978·Biochimica Et Biophysica Acta·J JänneA Raina
Aug 1, 1976·Acta Orthopaedica Scandinavica·N Dalén, B Lamke
Jan 1, 1992·Bone·J A Kanis, E V McCloskey
Oct 1, 1992·International Journal of Epidemiology·N KreigerG Hunter
Aug 1, 1992·Alcoholism, Clinical and Experimental Research·K IsenbergB W Moore
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C CooperL J Melton
Aug 25, 1992·Annals of Internal Medicine·C W SlemendaC C Johnston
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·R T CookA Yen
Aug 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A GrissoJ Portale
Jun 1, 1991·Metabolism: Clinical and Experimental·K E Friday, G A Howard
Jul 1, 1991·Journal of General Internal Medicine·D G SimonM Moore
Nov 1, 1991·Endocrinology·E CanalisT L McCarthy
Jul 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J LindholmC Schou
Jul 1, 1991·The American Journal of Clinical Nutrition·M Hernandez-AvilaW C Willett
Apr 1, 1991·Calcified Tissue International·K LaitinenP Keto
Dec 1, 1990·Biochemical Society Transactions·D M Morgan
Mar 1, 1990·Calcified Tissue International·R G Crilly, L Delaquerrière-Richardson
Mar 1, 1990·Calcified Tissue International·H K NielsenC Hansen
Jun 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P L Hoffman, B Tabakoff
Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·J B Hoek, E Rubin
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M DiehlN Brown
Sep 1, 1990·Journal of Studies on Alcohol·K M Flegal
Feb 1, 1990·The Journal of Clinical Investigation·A M DiehlC J Steer
Apr 8, 1989·BMJ : British Medical Journal·J C StevensonK F Ganger
Mar 1, 1989·The American Journal of Medicine·T DiamondS Posen
Jan 1, 1989·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·M LabibV Marks
Jan 19, 1985·Lancet·W J Boyce, M P Vessey
Jan 31, 1989·Biochemical and Biophysical Research Communications·T K GrayD J Baylink
Apr 1, 1985·Archives of Biochemistry and Biophysics·J R FarleyK H Lau
Jul 1, 1985·Annals of Internal Medicine·D D BikleG J Strewler
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A S GordonI Diamond
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I DiamondA Gordon
Jun 1, 1988·Molecular and Cellular Biology·B Lüscher, R N Eisenman
Oct 1, 1988·Alcoholism, Clinical and Experimental Research·T C PengJ R Hagaman
Mar 1, 1986·The Biochemical Journal·A E Pegg
Feb 21, 1987·British Medical Journal·E G Lucas
Aug 1, 1987·Calcified Tissue International·L J MeltonB L Riggs
Jan 1, 1987·Advances in Enzyme Regulation·G D Luk, R A Casero
Jan 1, 1988·Calcified Tissue International·M Garcia-CarrascoL Miravet

❮ Previous
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Citations

Jul 9, 2011·Rheumatology International·Neslihan Berkdemir SiverekliHasan Elden
Mar 26, 2011·European Journal of Applied Physiology·Delphine B MaurelChristelle Jaffre
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·L S Kidder, R T Turner
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F H WezemanN Lapaglia
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R T TurnerJ D Sibonga
Apr 1, 1999·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Z C Orlic, L G Raisz
Dec 23, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Isabel Chaves Silva CarvalhoRosilene Fernandes da Rocha
Aug 15, 2003·Clinics in Geriatric Medicine·Carolyn Becker
Jan 30, 2015·Dental press journal of orthodontics·Cristiano Miranda de AraujoOrlando Motohiro Tanaka
Jul 18, 2012·Public Health Nutrition·Isolde SommerMarjo Tuppurainen
Jul 25, 2013·CNS Drugs·Mark J Niciu, Albert J Arias
Nov 13, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jasmine ShiraziPooja Jain
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·K D Harper, T J Weber

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