Alcohol-induced injury of mitochondria in hepatocytes of mini-pig fetuses

Virchows Archiv. A, Pathological Anatomy and Histopathology
P Rømert, M E Matthiessen

Abstract

The present study describes the occurrence of abnormal mitochondria in the cytoplasm of hepatocytes from half-term mini-pig fetuses, whose mothers in addition to their ordinary fodder have received alcohol (ethanol) in daily amounts comparable to those consumed by human alcoholics. The abnormal mitochondria exhibit elongation and distortion, disorientation of cristae and the appearance of paracrystalline and electron-dense material in the matrix. These ultrastructural changes show striking similarities to the mitochondrial injuries seen initially in the hepatocytes of human alcoholics and probably reflect damage to the mitochondria caused by alcohol itself.

References

Mar 17, 1977·The New England Journal of Medicine·H L Bleich, E S Boro
Oct 1, 1968·Journal of Ultrastructure Research·H Voelz
Dec 8, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·P H Pikkarainen
Aug 15, 1970·American Journal of Obstetrics and Gynecology·P V Dilts
Jun 1, 1967·The Biochemical Journal·N C RäihäP Pikkarainen
May 1, 1967·Pediatric Research·P H Pikkarainen, N C Räihä
Dec 1, 1964·Journal of Ultrastructure Research·E MUGNAINI

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Citations

Mar 4, 2003·Journal of Cellular and Molecular Medicine·T Wakabayashi
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J Renau-PiquerasR Báguena-Cervellera
Nov 1, 1988·Journal of Dental Research·M E Matthiessen, P Rømert
May 10, 2019·International Journal of Environmental Research and Public Health·Anna N Bukiya
Mar 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·P Rømert, M E Matthiessen

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