Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen delivery

American Journal of Physiology. Heart and Circulatory Physiology
Mashkoor A ChoudhryIrshad H Chaudry

Abstract

Recent studies from our laboratory have shown that alcohol and burn injury impair intestinal barrier and immune functions. Although multiple factors can contribute to impaired intestinal barrier function, such an alteration could result from a decrease in intestinal blood flow (BF) and oxygen delivery (DO2). Therefore, in this study, we tested the hypothesis that alcohol ingestion before burn injury reduces splanchnic blood flow and oxygen delivery. Rats (250 g) were gavaged with alcohol to achieve a blood ethanol level in the range of 100 mg/dl before burn or sham injury (25% total body surface area). Day 1 after injury, animals were anesthetized with methoxyflurane. Blood pressure, cardiac output (CO), +/-dP/dt, organ BF (in ml.min(-1).100 g(-1)), and DO2 (in mg.ml(-1).100 g(-1)) were determined. CO and organ BF were determined using a radioactive microsphere technique. Our results indicate that blood pressure, CO, and +dP/dt were decreased in rats receiving a combined insult of alcohol and burn injury compared with rats receiving either burn injury or alcohol alone. This is accompanied by a decrease in BF and DO2 to the liver and intestine. No significant change in BF to the coronary arteries (heart), brain, lung, skin, and ...Continue Reading

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Citations

Jun 30, 2009·Journal of Emergencies, Trauma, and Shock·Mashkoor A Choudhry, Irshad H Chaudry
Aug 19, 2007·Alcoholism, Clinical and Experimental Research·Michael T ScalfaniFletcher A White
Apr 13, 2007·Alcoholism, Clinical and Experimental Research·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Mar 13, 2012·Critical Care Nursing Clinics of North America·Rebecca Coffey, Claire V Murphy
Aug 19, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael M ChenElizabeth J Kovacs
Feb 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Diane E DayTimothy J Bartness
Jan 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erin Keen-Rhinehart, Timothy J Bartness
Oct 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erin Keen-Rhinehart, Timothy J Bartness
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan J Dailey, Timothy J Bartness
Oct 22, 2011·Clinical Nurse Specialist CNS·Rebecca CoffeyEsther Chipps
Sep 24, 2020·Journal of Leukocyte Biology·Niya L MorrisMashkoor A Choudhry
May 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W A Cupples
Feb 13, 2021·Journal of Leukocyte Biology·Niya L Morris, Mashkoor A Choudhry
Apr 15, 2018·Alcohol·Holly J HulsebusElizabeth J Kovacs

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