PMID: 8609170Apr 1, 1996Paper

Alcohol inhibits cell-cell adhesion mediated by human L1

The Journal of Cell Biology
R RamanathanMichael E Charness

Abstract

Mental retardation, hydrocephalus, and agenesis of the corpus callosum are observed both in fetal alcohol syndrome (FAS) and in children with mutations in the gene for the cell adhesion molecule L1. We studied the effects of ethanol on cell-cell adhesion in mouse fibroblasts transfected with human L1. L1-transfected fibroblasts exhibited increased cell-cell adhesion compared with wild-type or vector-transfected controls. Ethanol potently and completely inhibited L1-mediated adhesion both in transfected L cells and NIH/3T3 cells. Half-maximal inhibition was observed at 7 mM ethanol, a concentration achieved in blood and brain after ingesting one alcoholic beverage. In contrast, ethanol did not inhibit the adhesion of fibroblasts transfected with vector alone or with N-CAM-140. L1-mediated cell-cell adhesion was inhibited with increasing potency by n-propanol and n-butanol, but was not inhibited at all by n-alcohols of 5 to 8 carbons, acetaldehyde, or acetate, suggesting that ethanol interacts directly with a small hydrophobic pocket within L1. Phenylalanine, teratogenic anticonvulsants, and high concentrations of glucose did not inhibit L1-mediated cell-cell adhesion. Ethanol also inhibited potently the heterotypic adhesion of r...Continue Reading

References

Jul 1, 1978·Neuropharmacology·M J McCreery, W A Hunt
Jan 1, 1978·The Journal of Pediatrics·S K ClarrenD W Smith
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G PeridesM E Charness
Jan 1, 1992·Journal of Molecular Neuroscience : MN·R A Reid, J J Hemperly
Nov 29, 1991·Brain Research·R O MessingJ J Park
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C Maguire, C M Regan
Oct 1, 1990·Genomics·P J WillemsS T Warren
Aug 16, 1990·The New England Journal of Medicine·J G Modell, J M Mountz
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·S SchenkerG I Henderson
Jan 1, 1990·The Journal of Cell Biology·G KadmonM Schachner
Aug 17, 1989·The New England Journal of Medicine·M E CharnessD A Greenberg
Jul 1, 1989·Human Genetics·R M WinterM N Patterson
Jul 1, 1986·Human Genetics·S KenwrickK E Davies
Jan 1, 1987·Drug and Alcohol Dependence·E L Abel, R J Sokol
Feb 1, 1985·The Journal of Cell Biology·M E Hatten
Nov 3, 1973·Lancet·K L Jones, D W Smith
Dec 9, 1982·Nature·N P Franks, W R Lieb
Jul 18, 1980·Science·A P StreissguthD W Smith
Jun 1, 1982·Teratology·J L Mills
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·N L DayN Robles
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·R RoivainenR O Messing
Feb 1, 1995·Molecular and Cellular Neurosciences·E J WilliamsP Doherty
Jan 15, 1993·The Journal of Comparative Neurology·P D MillerS T DeKosky
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·R W Peoples, F F Weight
Jan 23, 1995·Behavioural Brain Research·S P Rose
Mar 1, 1995·Journal of Neurobiology·P DohertyF S Walsh
Apr 1, 1995·Trends in Neurosciences·E V WongV Lemmon

❮ Previous
Next ❯

Citations

Feb 16, 1999·Teratology·E L Abel
Apr 5, 2002·Phytotherapy Research : PTR·V RajakrishnanV P Menon
May 20, 1998·Molecular Neurobiology·K C BreenF D Hayes
Mar 1, 2006·Experimental Brain Research·Cecilia P MargretRobert S Waters
Sep 15, 2004·Acta Neuropathologica·Hiromi Sakata-HagaYoshihiro Fukui
Apr 25, 2000·Brain Research. Developmental Brain Research·P A Yanni, T A Lindsley
Oct 2, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory Z Tau, Bradley S Peterson
Jan 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Enrique ArevaloKeith W Miller
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xiaowei DouMichael E Charness
Mar 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Johann K Eberhart, Robert Adron Harris
Jun 28, 2003·Neurotoxicity Research·Tomas PalomoRichard M Kostrzewa
Dec 13, 2003·Tissue Engineering·Jian-Ying ZhangJeffrey O Hollinger
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·M E Charness
Mar 26, 1998·Alcoholism, Clinical and Experimental Research·M M CartwrightS M Smith
Oct 2, 1998·Alcoholism, Clinical and Experimental Research·P A Clamp, T A Lindsley
Dec 11, 1999·Alcoholism, Clinical and Experimental Research·M F WilkemeyerM E Charness
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·Laura E NagyCynthia F Bearer
Jul 18, 2008·Science Signaling·R Adron HarrisS John Mihic
Aug 13, 2013·PloS One·Katica BoricKathleen Whitlock
May 11, 2012·Experimental & Molecular Medicine·Chun Hua Wei, Seong Eon Ryu
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael F WilkemeyerMichael E Charness
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·David A Greenberg
Jan 31, 2014·Brain : a Journal of Neurology·Timothy J EdwardsLinda J Richards
May 12, 2005·Developmental Neuroscience·Shao-Yu ChenKathleen K Sulik
Mar 20, 2010·Cellular and Molecular Life Sciences : CMLS·Michael K E Schäfer, Peter Altevogt
Jun 11, 2011·Critical Reviews in Clinical Laboratory Sciences·Silvia Alfonso-Loeches, Consuelo Guerri
Nov 4, 2015·Brain Sciences·Balapal S Basavarajappa
Apr 7, 2004·The Journal of Cell Biology·Kyoko ItohVance Lemmon
Dec 24, 2015·Alcohol·C Fernando ValenzuelaAnna Y Klintsova
Dec 12, 1997·Alcoholism, Clinical and Experimental Research·M L AikensF M Booyse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Michael F WilkemeyerMichael E Charness
The Journal of Pharmacology and Experimental Therapeutics
Michael F WilkemeyerMichael E Charness
© 2021 Meta ULC. All rights reserved