Alcohol inhibits spontaneous activity of basolateral amygdala projection neurons in the rat: involvement of the endocannabinoid system

Alcoholism, Clinical and Experimental Research
Simona PerraMarco Pistis

Abstract

A large body of evidence indicates that the limbic system is involved in the neural processing underlying drug addiction. Among limbic regions, the basolateral nucleus of amygdala (BLA) is implicated in some aspects of the neurobiological mechanisms of drugs of abuse, including alcohol and cannabinoids. It is recently emerging that the endocannabinoid system is involved in many pharmacological and behavioral effects of alcohol. The BLA possesses a very high density of CB1 cannabinoid receptors, and endocannabinoids modulate forms of synaptic plasticity in this region. The aims of our study were first to investigate in vivo the sensitivity of BLA pyramidal neurons to alcohol and second to determine the role of the endocannabinoid system in the acute effects of alcohol. We utilized extracellular single cell recordings in urethane anesthetized rats from BLA principal neurons, antidromically identified from their projection site in the nucleus accumbens. Alcohol (0.25 to 2.0 g/kg i.v.) induced a marked decrease in the spontaneous firing rate of BLA projecting neurons (51.1 +/- 16% of baseline at 0.5 g/kg alcohol, p < 0.0001). The involvement of the endogenous cannabinoid system was investigated by administering the CB1 receptor ant...Continue Reading

References

Mar 15, 1978·The Journal of Comparative Neurology·J E Krettek, J L Price
May 1, 1994·Trends in Neurosciences·M DavisM Cassell
Jan 22, 1993·The Journal of Comparative Neurology·L A MatsudaS J Lolait
Mar 26, 1998·Alcoholism, Clinical and Experimental Research·G F KoobF Weiss
May 5, 1998·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G ColomboG L Gessa
Apr 20, 1999·Psychopharmacology·J E Gallate, I S McGregor
Dec 20, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G F Koob, M Le Moal
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marisa RobertoGeorge R Siggins
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marisa RobertoGeorge R Siggins
Jun 23, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Sergio OrtizJorge Manzanares
Sep 24, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hakim HouchiMickaël Naassila
May 28, 2005·Pharmacology, Biochemistry, and Behavior·Sara GonzálezJavier Fernández-Ruiz
Jul 11, 2006·Neurochemistry International·K Yaragudri VinodBasalingappa L Hungund
Feb 17, 2007·The Biochemical Journal·Belen FerrerFernando Rodríguez de Fonseca
Mar 28, 2007·Alcoholism, Clinical and Experimental Research·Somsak MitrirattanakulIgor Spigelman
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stéphanie CailléLoren H Parsons
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anke Tappe-TheodorRohini Kuner

❮ Previous
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Citations

Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew N HillBoris B Gorzalka
May 14, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marisa RobertoPaul Schweitzer
Feb 27, 2009·Genes, Brain, and Behavior·H M B LesscherP M Newton
Nov 30, 2013·Biology of Mood & Anxiety Disorders·Matthew N Hill, Sachin Patel
Feb 15, 2011·International Journal of Environmental Research and Public Health·Salvador Manzo-Avalos, Alfredo Saavedra-Molina
Mar 18, 2009·World Journal of Gastroenterology : WJG·Angela Dolganiuc, Gyongyi Szabo
Jan 29, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shiva HashemizadehAmeneh Rezayof
Sep 18, 2008·Journal of Neurochemistry·Balapal S BasavarajappaOttavio Arancio
Jun 22, 2016·Pharmacology, Biochemistry, and Behavior·Sattar Norouzi OfoghZahra Ghasemzadeh
Dec 1, 2012·Balsaeng'gwa saengsig·Leeyup Chung
Jul 27, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew N HillSachin Patel
Jul 3, 2019·British Journal of Pharmacology·Balapal S BasavarajappaShivakumar Subbanna
Aug 26, 2020·Journal of Neurotrauma·Zachary F StielperNicholas W Gilpin
Mar 16, 2017·Frontiers in Cellular Neuroscience·Guang-Jian ZhangDe-Lai Qiu

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