Alcohol-Mediated Organ Damages: Heart and Brain

Frontiers in Pharmacology
Adam ObadSima T Tarzami

Abstract

Alcohol is one of the most commonly abused substances in the United States. Chronic consumption of ethanol has been responsible for numerous chronic diseases and conditions globally. The underlying mechanism of liver injury has been studied in depth, however, far fewer studies have examined other organs especially the heart and the central nervous system (CNS). The authors conducted a narrative review on the relationship of alcohol with heart disease and dementia. With that in mind, a complex relationship between inflammation and cardiovascular disease and dementia has been long proposed but inflammatory biomarkers have gained more attention lately. In this review we examine some of the consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver. The article reviews the potential role of inflammatory markers such as TNF-α in predicting dementia and/or cardiovascular disease. It was found that TNF-α could promote and accelerate local inflammation and damage through autocrine/paracrine mechanisms. Unraveling the mechanisms linking chronic alcohol consumption with proinflammatory cytokine production and subsequent inflammatory signaling pathways activation in the heart and CNS, is essen...Continue Reading

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Citations

Feb 27, 2020·Nutrients·Joaquim Fernández-Solà
Sep 12, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pablo Giménez-GómezMaria Isabel Colado
Jun 14, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Yu LiangTao Li
Aug 21, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Zahra Shabani, Mohsen Jafarzadeh Gharehziaaddin
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Oct 15, 2020·Acta neurologica Belgica·Gabriele CiprianiSabrina Danti

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