Alcohol-mediated tactile conditioned aversions in infant rats: devaluation of conditioning through alcohol-sucrose associations

Neurobiology of Learning and Memory
Juan Carlos MolinaNorman E Spear

Abstract

Three experiments were conducted to assess the plasticity of ethanol-mediated conditioned aversions to a tactile stimulus in infant rats. Ten- and 11-day-old rats first acquired an aversion to a texture, by virtue of its pairing with alcohol-induced intoxication. This first conditioning phase was followed by an associative devaluation procedure, a second phase in which sucrose was intraorally infused during alcohol-induced intoxication. Pups were then tested for their texture preference. Results indicated that infant rats readily express conditioned aversion to a tactile cue as a result of tactile-alcohol pairings and that this associative learning was not state dependent. When alcohol-texture conditioning was followed by sucrose-alcohol pairings, the magnitude of the texture aversion was dramatically reduced (Experiments 1 and 2). In Experiment 3 citric acid rather than sucrose was paired with alcohol intoxication following texture-alcohol pairings. The results indicated that this procedure strengthened texture conditioned aversions in terms of increased resistance to extinction. Taken as a whole these studies indicate that infants rapidly acquire alcohol-mediated texture aversions and that this memory is malleable and can be ...Continue Reading

Citations

Jul 30, 2008·The Behavioral and Brain Sciences·A David RedishAdam Johnson
Jun 14, 2006·Behavioral Neuroscience·Carlos Arias, M Gabriela Chotro
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·P AbateJ C Molina
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·M Y PepinoJ C Molina
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·P AbateJ C Molina
Jun 5, 2002·Alcoholism, Clinical and Experimental Research·Ricardo M PautassiJuan Carlos Molina
May 12, 2011·Journal of Pain Research·Andrea L Martin-PichoraJoel Katz
Mar 24, 2012·Alcohol·Michael E NizhnikovNorman E Spear
May 12, 2009·Neuroscience and Biobehavioral Reviews·Ricardo M PautassiNorman E Spear
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Ricardo Marcos PautassiJuan Carlos Molina
Mar 28, 2008·Alcoholism, Clinical and Experimental Research·Kelly A BordnerNorman E Spear
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Juan Carlos MolinaNorman E Spear
Oct 3, 2006·Neuroscience and Biobehavioral Reviews·M Gabriela ChotroGiovanni Laviola
Jan 21, 2012·Physiology & Behavior·Ricardo Marcos PautassiNorman E Spear
Jan 7, 2006·Alcohol·Ricardo Marcos PautassiJuan Carlos Molina
Jul 14, 2011·Psychopharmacology·Roberto Sebastián Miranda-MoralesPaula Abate
Apr 6, 2017·Frontiers in Behavioral Neuroscience·María B AcevedoJuan C Molina

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