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Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation

Alcoholism, Clinical and Experimental Research

Sep 17, 2013

Elia C El HajjJason D Gardner

Abstract

Chronic alcohol consumption has been shown in human and animal studies to result in collagen accumulation, myocardial fibrosis, and heart failure. Cardiac fibroblasts produce collagen and regulate extracellular matrix (ECM) homeostasis through the synthesis and activity of matrix metall...read more

Mentioned in this Paper

Ethanol
TIMP1 wt Allele
Specimen Type - Fibroblasts
Ethanol Measurement
Isoactin
Cirrhosis
N-Actin
Extracellular Matrix
Alcoholic Intoxication, Chronic
Test of Infant Motor Performance Survey
Paper Details
References
  • References35
  • Citations13
1234
  • References35
  • Citations13
12

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Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation

Alcoholism, Clinical and Experimental Research

Sep 17, 2013

Elia C El HajjJason D Gardner

PMID: 24033327

DOI: 10.1111/acer.12239

Abstract

Chronic alcohol consumption has been shown in human and animal studies to result in collagen accumulation, myocardial fibrosis, and heart failure. Cardiac fibroblasts produce collagen and regulate extracellular matrix (ECM) homeostasis through the synthesis and activity of matrix metall...read more

Mentioned in this Paper

Ethanol
TIMP1 wt Allele
Specimen Type - Fibroblasts
Ethanol Measurement
Isoactin
Cirrhosis
N-Actin
Extracellular Matrix
Alcoholic Intoxication, Chronic
Test of Infant Motor Performance Survey

Similar Papers Found In These Feeds

Lung Fibrosis & Scleroderma

Scleroderma is a chronic autoimmune disease that leads to hardening of connective tissues in the body. Lung fibrosis and disease is one of the leading causes of deaths in patients with scleroderma. Here is the latest research.

Extracellular Matrix Turnover

The extracellular matrix (ECM) ensures tissue integrity and play a role in cell growth, migration, and differentiation. ECM turnover, therefore, is essential for tissue maintenance. Here is the latest research on mechanisms that regulate ECM turnover.

Related Papers

Alcoholism, Clinical and Experimental Research

Activation of cardiac fibroblasts by ethanol is blocked by TGF-β inhibition

Alcoholism, Clinical and Experimental ResearchMarch 27, 2013
Brittany A Law, Wayne E Carver
Paper Details
References
  • References35
  • Citations13
1234
  • References35
  • Citations13
12
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