PMID: 11331201May 2, 2001Paper

Alcohol myopathy: impairment of protein synthesis and translation initiation

The International Journal of Biochemistry & Cell Biology
Charles H LangT C Vary

Abstract

Alcohol consumption leads to numerous morphological, biochemical and functional changes in skeletal and cardiac muscle. One such change observed in both tissues after either acute alcohol intoxication or chronic alcohol consumption is a characteristic decrease in the rate of protein synthesis. A decrease in translation efficiency appears to be responsible for at least part of the reduction. This review highlights advances in determining the molecular mechanisms by which alcohol impairs protein synthesis and places these observations in context of earlier studies on alcoholic myopathy. Both acute and chronic alcohol administration impairs translational control by modulating various aspects of peptide-chain initiation. Moreover, this alcohol-induced impairment in initiation is associated with a decreased availability of eukaryotic initiation factor (eIF) 4E in striated muscle, as evidenced by an increase in the amount of the inactive eIF4E.4E-BP1 complex and decrease in the active eIF4E.eIF4G complex. In contrast, alcohol does not produce consistent alterations in the control of translation initiation by the eIF2 system. The etiology of these changes remain unresolved. However, defects in the availability or effectiveness of vari...Continue Reading

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Citations

Aug 25, 2007·European Journal of Applied Physiology·M B PoulsenH Andersen
Sep 27, 2012·Cell Stress & Chaperones·Aminul IslamYifan Chen
Jun 29, 2005·The International Journal of Biochemistry & Cell Biology·Charles H LangThomas C Vary
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Oct 5, 2001·Alcoholism, Clinical and Experimental Research·L Q Hong-BrownC H Lang
Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Patricia E MolinaManuela Neuman
Dec 25, 2002·Alcoholism, Clinical and Experimental Research·Thomas C VaryCharles H Lang
Sep 28, 2012·Nutrients·Van Anh NguyenSuzanne M de la Monte
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·Robert A Frost, Charles H Lang
Mar 17, 2009·Acta histochemica·Uraporn VongvatcharanonSurapong Vongvatcharanon
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Charles H LangThomas C Vary
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Thomas C VaryCharles H Lang
Mar 27, 2003·Alcoholism, Clinical and Experimental Research·Patricia E MolinaJames M Crawford
Aug 11, 2006·Alcoholism, Clinical and Experimental Research·Ly Q Hong-BrownCharles H Lang
Jun 15, 2007·Alcoholism, Clinical and Experimental Research·Martin J J RonisJan Calissendorff
Jun 27, 2013·Alcoholism, Clinical and Experimental Research·Napoleon WaszkiewiczKrzysztof Zwierz
Feb 4, 2005·Metabolism: Clinical and Experimental·Thomas C Vary, Gina Deiter
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Mar 27, 2003·Alcoholism, Clinical and Experimental Research·Charles H LangThomas C Vary
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Joaquim Fernandez-SolàAlvaro Urbano-Márquez
Jan 28, 2015·Alcoholism, Clinical and Experimental Research·Jennifer L Steiner, Charles H Lang
Mar 22, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Patricia E MolinaLiz Simon
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Jeremy W DuncanJun Ming Wang
Apr 21, 2017·Alcoholism, Clinical and Experimental Research·Jennifer L Steiner, Charles H Lang
Jan 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·Charles H LangThomas C Vary
Feb 9, 2016·World Journal of Critical Care Medicine·Ashish Jitendra Mehta
Aug 22, 2018·Annual Review of Nutrition·Scot R Kimball, Charles H Lang
Feb 3, 2007·Muscle & Nerve·Jennifer S Moylan, Michael B Reid
Nov 22, 2007·Alcoholism, Clinical and Experimental Research·Roberto Vargas, Charles H Lang
Apr 14, 2005·American Journal of Physiology. Endocrinology and Metabolism·Ly Q Hong-BrownCharles H Lang
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas C VaryAndrew Sumner
Feb 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Charles H LangThomas C Vary
Mar 16, 2019·The Journal of Biological Chemistry·Sashi KantSrinivasan Dasarathy
Sep 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Thomas C VaryStacy A Goodman
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Charles H LangThomas C Vary
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Vinayshree KumarCharles H Lang
Aug 29, 2003·American Journal of Physiology. Endocrinology and Metabolism·Charles H LangScot R Kimball
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Oct 19, 2017·Alcoholism, Clinical and Experimental Research·Boris S ShenkmanTatiana L Nemirovskaya
Mar 18, 2015·Physiological Reports·Jennifer L SteinerCharles H Lang
Mar 12, 2015·American Journal of Physiology. Endocrinology and Metabolism·Jennifer L Steiner, Charles H Lang

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