Alcohol-related acute-on-chronic liver failure-Comparison of various prognostic scores in predicting outcome

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Ujjwal Sonika Shalimar

Abstract

Various prognostic scores are available for predicting outcome in acute-on-chronic liver failure (ACLF). We compared the available prognostic models as predictors of outcome in alcohol-related ACLF patients. All consecutive patients with alcohol-related ACLF were included. At admission, prognostic indices-acute physiology and chronic health evaluation score (APACHE II), model for end-stage liver disease (MELD), MELD-Na, Maddrey's discriminant function (DF), age-bilirubin-INR-creatinine (ABIC), and Chronic Liver Failure Consortium (CLIF-C) ACLF score (CLIF-C ACLF) score were calculated. Receiver operator characteristic (ROC) curves were plotted for all prognostic scores with in-hospital, 90-day, and 1-year mortality as outcome. Of the 171 patients, 170 were males, and grade 1 ACLF in 20 (11.7%), grade 2 in 52 (30.4%), and grade 3 in 99 (57.9%) patients. One hundred and nineteen (69.6%) died in-hospital. The median (IQR) Maddrey's score, MELD, MELD-Na, ABIC, APACHE II, and CLIF-C ACLF were 87.8 (66.5-123.0), 33.1 (27.6-40.0), 34.4 (29.5-40.0), 8.5 (7.3-9.6), 15 (12-21), and 51.1 (44.1-56.4), respectively. On multivariate Cox regression analysis, independent predictors of in-hospital outcome were presence of hepatic encephalopathy...Continue Reading

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Citations

Jun 15, 2019·Clinical and Molecular Hepatology·Guillermo Nahúm López-SánchezNatalia Nuño-Lámbarri
Dec 21, 2019·Advanced Pharmaceutical Bulletin·Nail Salavatovich AkhmadievValery Alekseevich Kataev
Mar 9, 2021·Journal of Clinical and Experimental Hepatology·Pankaj PuriManav Wadhawan

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