Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride.

Annals of General Psychiatry
Peter H SilverstoneSiobhan Fogarty

Abstract

Bupropion HCl is a widely used antidepressant that is known to cause seizures in a dose-dependent manner. Many patients taking antidepressants will consume alcohol, even when advised not to. Previous studies have not shown any interactions between bupropion HCl and alcohol. However, there have been no previous studies examining possible changes in seizure threshold induced by a combination of alcohol and bupropion HCl. Experimentally naïve female Swiss albino mice (10 per group) received either single doses of bupropion HCl (ranging from 100 mg/kg to 120 mg/kg) or vehicle (0.9% NaCl) by intraperitoneal (IP) injection in a dose volume of 10 ml/kg, and single-dose ethanol alone (2.5 g/kg), or vehicle, 5 min prior to bupropion dosing. The presence or absence of seizures, the number of seizures, the onset, duration and the intensity of seizures were all recorded for 5 h following the administration of ethanol. The results show that administration of IP bupropion HCl alone induced seizures in mice in a dose-dependent manner, with the 120 mg/kg dose having the largest effect. The percentage of convulsing mice were 0%, 20%, 30% and 60% in the 0 (vehicle), 100, 110, and 120 mg/kg dose groups, respectively. Pretreatment with ethanol pro...Continue Reading

References

May 1, 1975·Clinical Pharmacology and Therapeutics·T SeppäläM Mäki
Jan 1, 1984·European Journal of Clinical Pharmacology·J PosnerP Whiteman
Jan 1, 1984·European Journal of Clinical Pharmacology·M J HamiltonA W Peck
Jan 1, 1983·European Journal of Clinical Pharmacology·P DorianT Fan
Jan 1, 1980·Journal of Neural Transmission·J M Cott, S O Ogren
Aug 1, 1997·Clinical Pharmacokinetics·A G Fraser
Jan 16, 2003·The Medical Journal of Australia·Corrine R BalitGeoffrey K Isbister
Jul 21, 2004·The Journal of Emergency Medicine·Greene ShepherdDaniel C Keyes
Sep 15, 2004·European Journal of Pharmacology·Piotr TutkaMarian Wielosz
May 4, 2005·Epilepsy Research·Piotr TutkaMarian Wielosz
May 19, 2007·Journal of the American Pharmacists Association : JAPhA·Richard L BrownJames A Bobula

❮ Previous
Next ❯

Citations

Sep 20, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rahim GolmohammadiMohammad Mohammad-Zadeh
Aug 22, 2012·Current Psychiatry Reports·Jeffrey J DeVido, Roger D Weiss
Jun 27, 2009·Neuropsychiatric Disease and Treatment·David C HenshallPeter H Silverstone
Sep 25, 2012·Journal of Substance Abuse Treatment·Derek D SatreConstance Weisner
Nov 3, 2010·European Journal of Pharmacology·Bartłomiej BarczyńskiPiotr Tutka
Aug 16, 2016·Der Nervenarzt·N BehlerU Palm
Jun 17, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Oliver VranjkovicDanny G Winder
May 14, 2021·Journal of Addictive Diseases·Prabhat SapkotaAbhishek Ghosh
Sep 12, 2021·Epilepsy & Behavior : E&B·Yi GuoLiang Yu

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.