Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats

Alcohol
R AgabioG Colombo

Abstract

The present study was conducted to evaluate the effect of low doses of ethanol on motor activity in selectively bred Sardinian alcohol-preferring (sP) and Sardinian alcohol-nonpreferring (sNP) rats. Ethanol was acutely administered at the doses of 0, 0.25, and 0.5 g/kg (i.p.) immediately before rat exposure to an open-field arena for 15 min. The number of square crossings, used as index of motor activity, was significantly lower in saline-treated sP than in saline-treated sNP rats, suggestive of a genetically determined higher emotional state in sP than in sNP rats. Ethanol administration resulted in a dose-dependent, significant increase in the number of square crossings in sP rats, whereas it was completely ineffective in sNP rats. These results suggest to us that a positive relationship exists between ethanol preference and ethanol-induced motor stimulation in sP/sNP rat lines.

References

Jan 1, 1972·Psychopharmacologia·A CarlssonT H Svensson
Jun 1, 1995·Physiology & Behavior·G ColomboG L Gessa
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·P Päivärinta, E R Korpi
Jul 1, 1997·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G Colombo
Jun 23, 1960·Psychopharmacologia·G W READA FURST

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Citations

Feb 13, 2010·Addiction Biology·John C CrabbeCindy L Ehlers
Dec 8, 2011·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·E V FilatovaK O Kulagina
Nov 26, 2011·Reviews in the Neurosciences·Muhammad A ParvazRita Z Goldstein
Dec 10, 2013·Psychopharmacology·Caroline QuoilinEtienne Quertemont
Mar 19, 2014·Pharmacology, Biochemistry, and Behavior·Christian BrabantEtienne Quertemont
Dec 3, 2014·Physiology & Behavior·S CastelloC Arias
Apr 1, 2014·Alcohol·Giancarlo ColomboGian Luigi Gessa
Jan 10, 2012·Behavioural Brain Research·Caroline QuoilinEtienne Quertemont
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Z A RoddW J McBride
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Ann M Chappell, Jeff L Weiner
Dec 18, 2012·Alcoholism, Clinical and Experimental Research·Kenneth J D Allen, Frances H Gabbay
May 18, 2011·Alcoholism, Clinical and Experimental Research·Yan ZhouMary Jeanne Kreek
Oct 21, 2009·Developmental Psychobiology·Carlos AriasNorman E Spear
Dec 8, 2004·Pharmacology, Biochemistry, and Behavior·Zachary A RoddWilliam J McBride
Aug 29, 2006·Pharmacology, Biochemistry, and Behavior·Susan K ConroyR Andrew Chambers
Aug 6, 2013·Drug and Alcohol Dependence·Travis M Moschak, Suzanne H Mitchell
Apr 11, 2019·Neurological Research·Azam AlinaghipourAbolfazl Ardjmand
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Roberto U CofresíThomas M Piasecki

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