PMID: 8938818Oct 1, 1996Paper

Alcohol withdrawal and dopamine receptor sensitivity after prolonged abstinence

Progress in Neuro-psychopharmacology & Biological Psychiatry
G WiesbeckJ Boening

Abstract

1. Forty-four male inpatients suffering from moderate to severe alcohol dependence (DSM-III-R and ICD-10) as well as 14 healthy controls entered this study. Individuals were classified according to the severity of their withdrawal symptoms during detoxification i.e. group 1) no withdrawal, group 2) autonomic hyperactivity, group 3) withdrawal delirium and group 4) controls. 2. During the 6th week of treatment, that is, when all patients were recovered, controlled abstinent, and several weeks away from the end of their withdrawal syndrome, dopamine receptor sensitivity was neuroendocrinologically assessed by stimulating human growth hormone (HGH) with apomorphine (APO). 3. In a repeated measures model ANOVA, the four groups differed significantly in their HGH release. However, when excluding the controls from the analysis and focusing on alcoholics only (group 1 - 3), the significant difference disappeared. Covariates such as age, weight, quantity of drinking and duration of dependence were not related to the dependent variable. 4. In conclusion, the first significant result (with controls) reflects a blunted HGH response in alcoholics. It confirms earlier reports. The second, non significant result with the alcohol dependents o...Continue Reading

References

Aug 1, 1977·The Journal of Pharmacy and Pharmacology·B TabakoffF Moses
Sep 15, 1978·Deutsche medizinische Wochenschrift·H Beckmann, D Athen
Nov 1, 1976·Journal of Studies on Alcohol·A J Kahn, C L Scudder
May 1, 1985·Acta Physiologica Scandinavica·B MeisterM Goldstein
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Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Lal
Feb 1, 1982·Acta Psychiatrica Scandinavica·V Borg, T Weinholdt
Apr 1, 1993·Drug and Alcohol Dependence·J BalldinA Sundkler

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Citations

Aug 22, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·N M Ng Ying KinJ X Thavundayil
Jul 10, 1999·Psychoneuroendocrinology·M SmolkaM R Hoehe

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