Alcohol withdrawal-induced change in lipoprotein(a): association with the growth hormone/insulin-like growth factor-I (IGF-I)/IGF-binding protein-1 (IGFBP-1) axis

Arteriosclerosis, Thrombosis, and Vascular Biology
M PaassiltaY A Kesäniemi

Abstract

Lipoprotein(a) [Lp(a)] is an important risk factor for cardiovascular disease. Alcohol is one of the few nongenetic factors that lower Lp(a) levels, but the metabolic mechanisms of this action are unknown. Alcohol inhibits the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis. Alcohol might also affect IGF-binding protein-1 (IGFBP-1), which is an acute inhibitor of IGF-I. We studied how alcohol withdrawal affects Lp(a) levels and the GH/IGF-I/IGFBP-1 axis. Male alcohol abusers (n=27; 20 to 64 years old) were monitored immediately after alcohol withdrawal for 4 days. Twenty-six healthy men, mainly moderate drinkers, served as control subjects. Fasting blood samples were drawn to determine Lp(a), IGF-I, and IGFBP-1 (by ELISA, RIA, and immunoenzymometric assay, respectively). Nocturnal (12 hours) urine collection was performed in 9 alcoholics and 11 control subjects for GH analyses (RIA). The groups were similar in age and body mass index. Lp(a), GH, and IGF-I tended to be lower and IGFBP-1 higher in the alcoholics immediately after alcohol withdrawal than in the control subjects. During the 4-day observation in alcoholics, Lp(a) levels increased by 64% and IGF-I levels by 41%, whereas IGFBP-1 levels decreased by 59% (...Continue Reading

References

Oct 1, 1992·Alcoholism, Clinical and Experimental Research·C M HuangM Linnoila
Jul 1, 1992·The Journal of Clinical Investigation·E BoerwinkleH H Hobbs
Jun 1, 1990·The Journal of Clinical Investigation·A M Scanu, G M Fless
Nov 17, 1989·Science·G Utermann
Feb 1, 1989·Clinical Biochemistry·S W French
Jan 1, 1982·Annals of Nutrition & Metabolism·E MarthG M Kostner
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A J D'ErcoleL E Underwood
Oct 1, 1983·Clinical Endocrinology·J R Davis, W J Jeffcoate
Jun 1, 1995·Current Opinion in Lipidology·S M Marcovina, J D Morrisett
Feb 1, 1995·Current Opinion in Lipidology·L Berglund
Apr 6, 1994·JAMA : the Journal of the American Medical Association·E J SchaeferR I Levy
Jun 26, 1993·BMJ : British Medical Journal·H OlivecronaB Angelin
Jan 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinT Poynard
Aug 1, 1996·European Journal of Clinical Investigation·N von AhsenM Oellerich

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Citations

Jun 1, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H GrønbaekH Hey
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Jun 19, 2004·International Journal of Environmental Health Research·Francesco TomeiEnrico Tomao
May 31, 2003·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Francesco TomeiEnrico Tomao
Mar 30, 1999·Current Opinion in Lipidology·L Puckey, B Knight
Feb 19, 2000·Current Opinion in Lipidology·M F Laker
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·M PassiltaY A Kesäniemi
Aug 18, 2001·Journal of Endocrinological Investigation·S Röjdmark, K Brismar
Mar 12, 2003·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Giancesare Guidi

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