PMID: 7017761Jan 1, 1980Paper

Alcohol withdrawal seizures: implications of kindling

Pharmacology, Biochemistry, and Behavior
J P Pinel

Abstract

The periodic administration of convulsive agents, even at doses or intensities that initially have no convulsive effect, can lead to a progressive and enduring increase in the susceptibility to subsequent convulsive stimulation. This kindling effect has contributed to the understanding of the convulsive effects of alcohol withdrawal in three ways. First, rats kindled by the periodic application of electroconvulsive shock, local brain stimulation, or pentylenetetrazol were found to be hypersusceptible to the convulsive effects of subsequent alcohol withdrawal, thus raising the possibility that some forms of electrical or pharmacological therapy can potentiate the alcohol withdrawal syndrome in humans. Second, the duration of seizures elicited in kindled rats has been used as a sensitive index of convulsive withdrawal effects; increases in the duration of kindled motor seizures and afterdischarges can be detected following the metabolism of a single intoxicating injection of ethanol. Third, it was suggested that the potentiation of the convulsive effects of alcohol exposure and withdrawal by prior episodes of alcohol withdrawal may reflect a kindling-like process rather than an increase in physical dependence.

References

Sep 1, 1978·Neurosurgery·R Racine
Jan 15, 1978·Experimental Neurology·J P Pinel, L I Rovner
Feb 1, 1977·Experimental Neurology·R F Mucha, P J Pinel
May 1, 1977·Pharmacology, Biochemistry, and Behavior·J P Pinel, K F Cheung
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Mar 1, 1974·Electroencephalography and Clinical Neurophysiology·D W Walker, S F Zornetzer

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Citations

Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·D P Cain
Jan 1, 1982·Progress in Neurobiology·S L Peterson, T E Albertson
Mar 1, 1986·Alcohol·D Butler, F S Messiha
May 26, 1999·Pharmacology, Biochemistry, and Behavior·M C Mhatre, L P Gonzalez
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·M DavidsonP A Wilce
Jul 1, 1999·Alcohol·S K AchesonH S Swartzwelder
Mar 27, 1999·The New England Journal of Medicine·G D'OnofrioE S Freedland
May 27, 1997·Neuroreport·L M Veatch, L P Gonzalez
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David N Stephens, Theodora Duka
Jan 17, 2004·The European Journal of Neuroscience·T L RipleyD N Stephens
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·Theodora DukaDavid N Stephens
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Theodora DukaFulton T Crews
May 20, 2003·The European Journal of Neuroscience·Tamzin L RipleyDavid N Stephens
Dec 1, 1993·Alcoholism, Clinical and Experimental Research·T J McCown, G R Breese
Aug 11, 2007·Nature Reviews. Drug Discovery·Caryn LermanWilliam A Corrigall
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Hilary J LittleChristopher Cunningham
Jan 1, 1984·Acta Neurologica Scandinavica·M E Hillbom, M Hjelm-Jäger
Dec 24, 2009·Alcoholism, Clinical and Experimental Research·Janne D OllingDavid P D Woldbye
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·L P GonzalezH C Becker
Apr 1, 1996·Alcoholism, Clinical and Experimental Research·L M Veatch, L P Gonzalez
Oct 18, 2002·The European Journal of Neuroscience·Tamzin L RipleyDavid N Stephens
Mar 9, 2021·Brain Plasticity·Sreetama Basu, Hoonkyo Suh
Sep 1, 1993·The Journal of Emergency Medicine·E S Freedland, D B McMicken
Jul 1, 1993·The Journal of Emergency Medicine·E S Freedland, D B McMicken
Jul 22, 2021·Addiction·Ed Day, Chris Daly

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