PMID: 6108298Jan 1, 1980Paper

Alcohol withdrawal syndrome: treatment with trazodone

International Pharmacopsychiatry
G RoccatagliataS Farelli

Abstract

Central monoaminergic pathways dysfunction has been shown in the alcohol withdrawal syndrome of experimental animals: noradrenergic hyperfunction and serotonin transmission impairment is suggested by many studies. Trazodone is a new psychotropic drug which has a marked norepinephrine receptor blocking power; moreover, it inhibits serotonin reuptake and was fully effective in the treatment of man's withdrawal syndrome (17 alcoholic inpatients). The good therapeutical results make it conceivable that monoaminergic pathways dysfunction has an important pathophysiological role in the alcohol withdrawal syndrome of man also.

Citations

Jun 21, 2012·Expert Opinion on Pharmacotherapy·Letizia BossiniAndrea Fagiolini
Jul 12, 2008·Alcoholism, Clinical and Experimental Research·Peter D FriedmannMichael D Stein
Apr 22, 2003·Journal of Addictive Diseases·Peter D FriedmannMichael D Stein
Jun 1, 1999·Journal of Clinical Psychopharmacology·Y OkamotoS Yamawaki
Feb 3, 2021·Translational Psychiatry·Zeljka KoradeKaroly Mirnics
Mar 17, 2004·Sleep Medicine Reviews·Kirk J Brower

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